Associations With Changes in Disease-Specific Quality of Life Following Stereotactic Radiosurgery for Sporadic Vestibular Schwannoma.

IF 2.6 3区医学 Q1 OTORHINOLARYNGOLOGY

Otolaryngology- Head and Neck Surgery Pub Date : 2025-04-04 DOI:10.1002/ohn.1243

Eric E Babajanian, Ghazal S Daher, James R Dornhoffer, Karl R Khandalavala, John P Marinelli, Christine M Lohse, Michael J Link, Matthew L Carlson

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引用次数: 0

Abstract

Objective: To examine associations with changes in quality-of-life (QOL) outcomes following treatment of vestibular schwannoma (VS) using stereotactic radiosurgery (SRS).

Study design: Prospective longitudinal study.

Setting: Tertiary academic center.

Methods: Patients who were treated for sporadic VS using SRS from 2015 to 2022 were included. QOL outcomes were measured using the disease-specific Penn Acoustic Neuroma QOL (PANQOL) scale.

Results: Seventy-nine patients with pre-SRS and at least one post-SRS PANQOL assessments were available for analysis. The mean change in total PANQOL scores was -2 (SD 13) on a 100-point scale. The mean duration between assessments was 4.6 years (SD 2.0). Age at SRS, sex, and SRS treatment doses were not significantly associated with changes in total PANQOL scores. Total PANQOL scores improved a mean of 4 points for patients with tumors confined to the internal auditory canal but declined a mean of 5 points for patients with tumors extending into the cerebellopontine angle (P = .01); however, these changes did not exceed the minimum clinically significant threshold of 11 points. The correlation coefficient between treated tumor volume at SRS and change in total PANQOL scores was -0.30 (P = .007). Changes in PANQOL total (P = .5) and hearing domain (P = .3) scores for patients who maintained serviceable hearing or progressed to nonserviceable hearing did not significantly differ.

Conclusion: Tumor extent and treated volume at SRS had a statistically significant but likely not clinically important impact on total PANQOL scores. Progression to nonserviceable hearing did not have a significant impact on PANQOL total or hearing domain scores.

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散发性前庭神经丛神经瘤立体定向放射外科手术后与特定疾病生活质量变化的关系

目的：探讨立体定向放射外科（SRS）治疗前庭神经鞘瘤（VS）后与生活质量（QOL）结果变化的关系。研究设计：前瞻性纵向研究。环境：高等教育学术中心。方法：纳入2015 - 2022年使用SRS治疗散发性VS的患者。使用疾病特异性Penn听神经瘤QOL （PANQOL）量表测量QOL结果。结果：79例srs前患者和至少1例srs后PANQOL评估可用于分析。PANQOL总分在100分制中平均变化为-2 （SD 13）。两次评估之间的平均持续时间为4.6年（SD 2.0）。SRS时的年龄、性别和SRS治疗剂量与PANQOL总分的变化无显著相关。肿瘤局限于内耳道的患者PANQOL总分平均提高了4分，肿瘤延伸至桥小脑角的患者PANQOL总分平均下降了5分（P = 0.01）；然而，这些变化没有超过11分的最低临床意义阈值。SRS时治疗肿瘤体积与PANQOL总评分变化的相关系数为-0.30 （P = .007）。维持听力正常或进展为听力不正常的患者PANQOL总分（P = 0.5）和听力域（P = 0.3）评分的变化无显著差异。结论：SRS时的肿瘤范围和治疗体积对PANQOL总评分有统计学意义，但可能没有临床意义。进展到无法使用听力对PANQOL总分或听力领域评分没有显著影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Otolaryngology- Head and Neck Surgery 医学-耳鼻喉科学

CiteScore

6.70

自引率

2.90%

发文量

250

审稿时长

2-4 weeks

期刊介绍： Otolaryngology–Head and Neck Surgery (OTO-HNS) is the official peer-reviewed publication of the American Academy of Otolaryngology–Head and Neck Surgery Foundation. The mission of Otolaryngology–Head and Neck Surgery is to publish contemporary, ethical, clinically relevant information in otolaryngology, head and neck surgery (ear, nose, throat, head, and neck disorders) that can be used by otolaryngologists, clinicians, scientists, and specialists to improve patient care and public health.