Rapid Differentiation of False Positives of Galactomannan Related to Contaminated Intravenous Fluids via a Pharmacokinetics Model and Innovative Web-Based Tool.

IF 3.8 4区医学 Q2 IMMUNOLOGY

Open Forum Infectious Diseases Pub Date : 2025-04-03 eCollection Date: 2025-04-01 DOI:10.1093/ofid/ofaf088

Raeseok Lee, Suein Choi, Hwajun Cha, Dukhee Nho, Sung-Yeon Cho, Seunghoon Han, Dong-Gun Lee

引用次数: 0

Abstract

This study developed a pharmacokinetic model and web-based tool to distinguish true invasive aspergillosis from false positives caused by contaminated fluids. By analyzing galactomannan kinetics, false positives were identified within 24 hours, improving diagnostic accuracy and aiding clinicians in early decision making while minimizing unnecessary interventions.

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通过药代动力学模型和基于网络的创新工具，快速区分与静脉注射液污染有关的半乳甘露聚糖假阳性。

本研究开发了一种药代动力学模型和基于网络的工具来区分真正的侵袭性曲霉病和由污染液体引起的假阳性。通过分析半乳甘露聚糖动力学，可以在24小时内识别假阳性，提高诊断准确性，帮助临床医生早期决策，同时最大限度地减少不必要的干预。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Forum Infectious Diseases Medicine-Neurology (clinical)

CiteScore

6.70

自引率

4.80%

发文量

630

审稿时长

9 weeks

期刊介绍： Open Forum Infectious Diseases provides a global forum for the publication of clinical, translational, and basic research findings in a fully open access, online journal environment. The journal reflects the broad diversity of the field of infectious diseases, and focuses on the intersection of biomedical science and clinical practice, with a particular emphasis on knowledge that holds the potential to improve patient care in populations around the world. Fully peer-reviewed, OFID supports the international community of infectious diseases experts by providing a venue for articles that further the understanding of all aspects of infectious diseases.