Rising rates of hospitalization for dementia in people with type 2 diabetes and the general population in Australia.

IF 3.4 3区 医学 Q2 NEUROSCIENCES
Kanika Mehta, Jedidiah I Morton, Agus Salim, Kaarin J Anstey, Jonathan E Shaw, Dianna J Magliano
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Abstract

BackgroundFew recent studies have examined the trends in dementia hospitalization in high-income countries.ObjectiveTo estimate the trends in hospitalization for dementia in people with type 2 diabetes (T2DM) and the general population in Australia using linked, national databases.MethodsAustralians with T2DM and registered on the National Diabetes Services Scheme (n = 438,264), and the general population (n = 8,090,993) from 2010-2011 to 2016-2017 served as the study cohort. Annual rates of hospitalization for dementia were calculated for these individuals aged ≥50 years. Following this, the trends in the rate of hospitalization were estimated using joinpoint regression and summarized as annual percent changes (APCs).ResultsIncreases in hospitalization for dementia over time were observed for the T2DM and the general population; APC 5.2 (95% CI 3.5, 7.3) and 9.4 (95% CI 3.8, 14.3), respectively. The absolute age- and sex-standardized rate of dementia hospitalization was found to be higher in the T2DM than the general population. For vascular dementia, a higher rate of hospitalization was observed for the T2DM population compared to the general population. Conversely, the rate of hospitalization for Alzheimer's disease was higher in the general population than in the T2DM cohort. Further, a higher dementia hospitalization rate was observed among males compared to females in both T2DM, and the general population.ConclusionsDespite the previous studies reporting a decline in dementia incidence in high-income countries, the rate of dementia hospitalization in Australia has risen steadily from 2010-2016 in both T2DM individuals and the general population.

澳大利亚 2 型糖尿病患者和普通人群中因痴呆症住院的比例不断上升。
最近很少有研究调查了高收入国家痴呆症住院的趋势。目的:利用相关的国家数据库,评估澳大利亚2型糖尿病(T2DM)患者和普通人群因痴呆症住院的趋势。方法将2010-2011年至2016-2017年期间在国家糖尿病服务计划中登记的2型糖尿病患者(n = 438,264)和普通人群(n = 8,090,993)作为研究队列。计算年龄≥50岁的老年痴呆症患者的年住院率。在此之后,使用连接点回归估计住院率的趋势,并将其总结为年度百分比变化(APCs)。结果T2DM患者和普通人群因痴呆住院的人数随时间增加;APC分别为5.2 (95% CI 3.5, 7.3)和9.4 (95% CI 3.8, 14.3)。T2DM患者的绝对年龄和性别标准化痴呆住院率高于一般人群。对于血管性痴呆,T2DM患者的住院率高于一般人群。相反,普通人群中阿尔茨海默病的住院率高于2型糖尿病患者。此外,在2型糖尿病患者和一般人群中,男性的痴呆症住院率均高于女性。尽管先前的研究报告了高收入国家痴呆症发病率的下降,但从2010年至2016年,澳大利亚T2DM患者和普通人群的痴呆症住院率都在稳步上升。
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来源期刊
Journal of Alzheimer's Disease
Journal of Alzheimer's Disease 医学-神经科学
CiteScore
6.40
自引率
7.50%
发文量
1327
审稿时长
2 months
期刊介绍: The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.
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