The effect of ambulatory blood pressure load on mitral regurgitation in continuous ambulatory peritoneal dialysis patients.

IF 1.7 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Open Medicine Pub Date : 2025-04-01 eCollection Date: 2025-01-01 DOI:10.1515/med-2025-1155

Qingyun Li, Xinqiang Zhong, Tongxia Cui, Bairong Chen, Weiping Zhu

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引用次数: 0

Abstract

Background: Hypertension is a risk factor for cardiovascular disease. The present study aimed to explore the impact of ambulatory blood pressure load (BPL) on mitral regurgitation (MR) in continuous ambulatory peritoneal dialysis (CAPD) patients.

Methods: A total of 215 CAPD patients hospitalized in the Department of Nephrology at the Fifth Affiliated Hospital of Sun Yat-sen University between November 2017 and June 2022 were included in the study. All subjects underwent 24-h ambulatory BP monitoring and an echocardiography examination. BPL and MR area (MRA) were calculated. Subjects were divided into high regurgitation group and non-high regurgitation group. General data were also collected. The effect of ambulatory BPL on MR in CAPD patients was analyzed using multiple linear regression.

Results: Baseline data comparison revealed statistically significant differences in hemoglobin, serum β₂-microglobulin, NT-proBNP, left atrial diameter (LAD), left ventricular end-diastolic diameter (LVDD), LV ejection fraction (LVEF), LV fractional shortening (LVFS), and mitral valve calcification between the high and non-high regurgitation groups (P < 0.05). There was no statistically significant difference in other clinical characteristics. Correlation analysis showed correlations between MRA and 24-h systolic BPL (24h-SBPL), 24-h diastolic BPL (24h-DBPL), daytime systolic BPL (D-SBPL), daytime DBPL (D-DBPL), nighttime systolic BPL (N-SBPL), nighttime DBPL (N-DBPL), hemoglobin level, NT-proBNP level, LAD, LVDD, LVEF, and LVFS. Multiple linear regression analysis revealed that the effects of 24h-DBPL and D-DBPL on MRA were statistically significantly different (P < 0.05).

Conclusions: Ambulatory BPL, particularly 24h-DBPL and D-DBPL, significantly affected MR. Therefore, controlling BPL, especially DBPL, was essential for reducing the incidence of cardiovascular events and clinical mortality in CAPD patients.

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持续不卧床腹膜透析患者的卧床血压负荷对二尖瓣反流的影响。

背景：高血压是心血管疾病的危险因素：高血压是心血管疾病的危险因素之一。本研究旨在探讨持续非卧床腹膜透析（CAPD）患者卧床血压负荷（BPL）对二尖瓣反流（MR）的影响：研究共纳入2017年11月至2022年6月期间在中山大学附属第五医院肾内科住院的215例CAPD患者。所有受试者均接受了24小时动态血压监测和超声心动图检查。计算BPL和MR面积（MRA）。受试者分为高反流组和非高反流组。同时还收集了一般数据。采用多元线性回归分析了流动 BPL 对 CAPD 患者 MR 的影响：基线数据比较显示，高反流组和非高反流组之间在血红蛋白、血清β2-微球蛋白、NT-proBNP、左心房直径（LAD）、左心室舒张末期直径（LVDD）、左心室射血分数（LVEF）、左心室折返缩短率（LVFS）和二尖瓣钙化方面的差异有统计学意义（P < 0.05）。其他临床特征的差异无统计学意义。相关性分析显示，MRA 与 24 小时收缩期 BPL（24h-SBPL）、24 小时舒张期 BPL（24h-DBPL）、日间收缩期 BPL（D-SBPL）、日间 DBPL（D-DBPL）、夜间收缩期 BPL（N-SBPL）、夜间 DBPL（N-DBPL）、血红蛋白水平、NT-proBNP 水平、LAD、LVDD、LVEF 和 LVFS 之间存在相关性。多元线性回归分析表明，24h-DBPL 和 D-DBPL 对 MRA 的影响在统计学上有显著差异（P < 0.05）：结论：非卧床 BPL，尤其是 24h-DBPL 和 D-DBPL，对 MR 有明显影响。因此，控制 BPL，尤其是 DBPL，对于降低 CAPD 患者的心血管事件发生率和临床死亡率至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Medicine Medicine-General Medicine

CiteScore

3.00

自引率

0.00%

发文量

153

审稿时长

20 weeks

期刊介绍： Open Medicine is an open access journal that provides users with free, instant, and continued access to all content worldwide. The primary goal of the journal has always been a focus on maintaining the high quality of its published content. Its mission is to facilitate the exchange of ideas between medical science researchers from different countries. Papers connected to all fields of medicine and public health are welcomed. Open Medicine accepts submissions of research articles, reviews, case reports, letters to editor and book reviews.