Three undescribed diterpenoids from Pini Lignum Nodi with hepatoprotective activities.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-04-04 DOI:10.1080/10286020.2025.2481289

Jia-Qi Chen, Ling-Zhi Zhang, Jie Ma, Chuang-Jun Li, Ying-Da Zang, Hua Sun, Dong-Ming Zhang

引用次数: 0

Abstract

Three new abietane-type diterpenes, named pinusins A-C (1-3) were isolated from Pini Lignum Nodi (the dried tuberculate or branched nodes of Pinus massoniana Lamb.), together with five known diterpenoids (4-8), a flavonoid (9) and a monoterpene (10). The structures of these compounds were elucidated based on detailed spectroscopic analyses (1D, 2D NMR, HRESIMS, IR, and UV), while ECD calculations determined their absolute configurations. All compounds were assayed in vitro for their protective activities against acetaminophen (APAP)-induced hepatotoxicity at 10 μM. Compounds 1-4, 9, and 10 experimentally exerted protective effects against APAP-induced HepG2 cell damage.

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从 Pini Lignum Nodi（Pinus massoniana Lamb.的干燥小瘤节或分枝节）中分离出了三种新的阿比坦类二萜，命名为 pinusins A-C（1-3），此外还有五种已知的二萜类化合物（4-8）、一种黄酮类化合物（9）和一种单萜类化合物（10）。这些化合物的结构是通过详细的光谱分析（一维、二维核磁共振、HRESIMS、红外光谱和紫外光谱）阐明的，而 ECD 计算则确定了它们的绝对构型。所有化合物都在体外进行了检测，以确定它们在 10 μM 的浓度下对对乙酰氨基酚（APAP）诱导的肝毒性具有保护活性。实验结果表明，化合物 1-4、9 和 10 对 APAP 诱导的 HepG2 细胞损伤具有保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.