Does HCV treatment completion affect the neurocognitive outcomes in patients on opioid agonist maintenance treatment: A secondary analysis.

IF 1.7 4区医学 Q3 PSYCHIATRY

Indian Journal of Psychiatry Pub Date : 2025-02-01 Epub Date: 2025-02-19 DOI:10.4103/indianjpsychiatry.indianjpsychiatry_900_24

Abhishek Ghosh, Abhishek Verma, Arka De, Madhumita Premkumar, Ajay Duseja, Ritu Nehra, Debasish Basu

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引用次数: 0

Abstract

Aim: This secondary analysis investigated whether completing Direct-Acting Antiviral (DAA) treatment affects neurocognitive outcomes in patients with opioid use disorder (OUD) undergoing opioid agonist maintenance treatment (OAMT).

Methods: Data from 45 participants (22 DAA treatment completers and 23 non-completers) were analyzed. Neurocognitive function was assessed at baseline and six months using the Wisconsin Card Sorting Test (WCST), Trail Making Tests (TMT A and B), Visual and Verbal N-Back tests, and Iowa Gambling Task (IGT).

Results: General Linear Model (GLM) analysis revealed significant improvements in cognitive function over time in both groups, with notable gains in WCST total correct responses (P < .001) and Visual Working Memory 2 Back hits and errors (P < .001). A significant Group × Time was found for TMT-B completion time, with non-completers showing greater improvement (P = .039).

Conclusion: These findings highlight that even incomplete DAA treatment, alongside OAMT, yields significant cognitive benefits, underscoring the importance of integrated care.

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HCV治疗完成是否会影响阿片类激动剂维持治疗患者的神经认知结局：一项次要分析。

目的：这项二次分析调查了完成直接作用抗病毒药物（DAA）治疗是否会影响接受阿片激动剂维持治疗（OAMT）的阿片类药物使用障碍（OUD）患者的神经认知结果：分析了45名参与者（22名完成DAA治疗者和23名未完成治疗者）的数据。在基线和6个月时，使用威斯康星卡片分类测试（WCST）、路径制作测试（TMT A和B）、视觉和言语N-Back测试以及爱荷华赌博任务（IGT）对神经认知功能进行评估：通用线性模型（GLM）分析表明，随着时间的推移，两组患者的认知功能都有显著改善，其中 WCST 总正确率（P < .001）和视觉工作记忆 2 回的命中率和错误率（P < .001）显著提高。在 TMT-B 完成时间方面，发现了明显的组别 × 时间关系，未完成者的进步更大（P = .039）：这些研究结果表明，即使是不完全的 DAA 治疗，与 OAMT 同时进行，也能产生显著的认知益处，从而强调了综合护理的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Indian Journal of Psychiatry Medicine-Psychiatry and Mental Health

CiteScore

4.40

自引率

3.20%

发文量

130

审稿时长

34 weeks

期刊介绍： The Indian Journal of Psychiatry (ISSN 0019-5545), is an official publication of the Indian Psychiatric Society. It is published Bimonthly with one additional supplement (total 5 issues). The IJP publishes original work in all the fields of psychiatry. All papers are peer-reviewed before publication. The issues are published Bimonthly. An additional supplement is also published annually. Articles can be submitted online from www.journalonweb.com . The journal provides immediate free access to all the published articles. The journal does not charge the authors for submission, processing or publication of the articles.