Gene-level connections between anxiety disorders, ADHD, and head and neck cancer: insights from a computational biology approach.

IF 3.2 3区医学 Q2 PSYCHIATRY

Frontiers in Psychiatry Pub Date : 2025-03-20 eCollection Date: 2025-01-01 DOI:10.3389/fpsyt.2025.1552815

Meng Lian, Haiyang Li, Zhiyang Zhang, Jugao Fang, Xiaoqin Liu

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引用次数: 0

Abstract

Background: Anxiety disorders (AD), ADHD, and head and neck cancer (HNC) are complex conditions with potential genetic interconnections that remain to be fully elucidated. The purpose of this study is to investigate gene-level connections among ADHD, AD, and HNC.

Method: A comprehensive literature mining approach identified potential gene-disease relationships from PubMed and bioinformatics databases, analyzing 19,924 genes. An AI-driven computational process constructed a gene-disease relationship table using the Adjusted Binomial Method Algorithm (ABMA) to evaluate association reliability. Overlapping genes were analyzed through protein-protein interaction (PPI) networks, functional annotations, and literature-based pathway analyses to elucidate shared and unique genetic mechanisms linking these diseases.

Results: The analysis identified 141 significant genes associated with AD, 153 with ADHD, and 1,065 with HNC (q-value < 0.05). These genes demonstrated significant overlap (odds ratio ≥ 1.8; p ≤ 2.58E-2) and high interconnectivity (PPI network density ≥ 0.39, clustering coefficient ≥ 0.76, and diameter ≤ 3). Centrality analysis revealed core genes such as IL-6, MYC, NLRP3, and CXCR4 as critical mediators. Functional enrichment analysis identified key pathways, including serotonergic synapse, inflammatory response, and Toll-like receptor signaling, highlighting the involvement of neuronal and immune mechanisms. Functional pathway analysis demonstrated reciprocal genetic influences among AD, ADHD, and HNC, emphasizing shared and distinct gene-level connections that may underlie their co-occurrence and mutual risk factors.

Conclusion: This study reveals a complex and interconnected genetic network among AD, ADHD, and HNC, highlighting shared pathways, unique mechanisms, and critical genes, providing valuable insights into the genetic underpinnings of these conditions and potential avenues for therapeutic exploration.

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焦虑障碍、多动症和头颈癌之间的基因水平联系：来自计算生物学方法的见解。

背景：焦虑症（AD）、多动症（ADHD）和头颈癌（HNC）是复杂的疾病，其潜在的遗传联系仍有待充分阐明。本研究的目的是探讨ADHD、AD和HNC之间的基因水平联系。方法：采用综合文献挖掘方法，从PubMed和生物信息学数据库中确定潜在的基因与疾病的关系，分析了19,924个基因。人工智能驱动的计算过程利用调整二项法算法（ABMA）构建基因-疾病关系表，评估关联可靠性。通过蛋白-蛋白相互作用（PPI）网络、功能注释和基于文献的通路分析来分析重叠基因，以阐明与这些疾病相关的共同和独特的遗传机制。结果：分析发现141个与AD相关的显著基因，153个与ADHD相关，1065个与HNC相关（q值< 0.05）。这些基因存在显著的重叠(优势比≥1.8；p≤2.58E-2)，互联性高（PPI网络密度≥0.39，聚类系数≥0.76，直径≤3）。中心性分析显示，IL-6、MYC、NLRP3、CXCR4等核心基因是关键的调节因子。功能富集分析确定了关键通路，包括血清素能突触、炎症反应和toll样受体信号，强调了神经元和免疫机制的参与。功能通路分析显示了AD、ADHD和HNC之间相互的遗传影响，强调了它们共同发生和相互危险因素背后的共享和独特的基因水平联系。结论：本研究揭示了AD、ADHD和HNC之间复杂而相互关联的遗传网络，突出了共同的途径、独特的机制和关键基因，为这些疾病的遗传基础和潜在的治疗探索途径提供了有价值的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Psychiatry Medicine-Psychiatry and Mental Health

CiteScore

6.20

自引率

8.50%

发文量

2813

审稿时长

14 weeks

期刊介绍： Frontiers in Psychiatry publishes rigorously peer-reviewed research across a wide spectrum of translational, basic and clinical research. Field Chief Editor Stefan Borgwardt at the University of Basel is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. The journal''s mission is to use translational approaches to improve therapeutic options for mental illness and consequently to improve patient treatment outcomes.