Xinlei Zhang, Zengze Yuan, Xiawei Shi, Junchao Yang
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引用次数: 0
Abstract
Background: Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible interstitial lung disease characterized by high mortality rates. An expanding body of evidence highlights the critical role of targeted therapies in the management of IPF. Nevertheless, there is a paucity of bibliometric studies that have comprehensively assessed this domain. This study seeks to examine global literature production and research trends related to targeted therapies for IPF.
Method: A literature search was conducted using the Web of Science Core Collection, encompassing publications from 2004 to 2024, focusing on targeted therapies for IPF. The bibliometric analysis utilized tools such as VOSviewer, CiteSpace, and the "bibliometrix" package in R.
Results: A total of 2,779 papers were included in the analysis, demonstrating a general trend of continuous growth in the number of publications over time. The United States contributed the highest number of publications, totaling 1,052, while France achieved the highest average citation rate at 75.74. The University of Michigan Medical School was the leading institution in terms of publication output, with 88 papers. Principal Investigator Naftali Kaminski was identified as the most prolific researcher in the field. The American Journal of Respiratory Cell and Molecular Biology emerged as the journal with the highest number of publications, featuring 98 articles. In recent years, the research has emerged surrounding targeted therapies for IPF, particularly focusing on agents such as TGF-β, pathogenesis, and autotaxin inhibitor.
Conclusion: In this bibliometric study, we systematically analyze research trends related to targeted therapies for IPF, elucidating recent research frontiers and emerging directions. The selected keywords-idiopathic pulmonary fibrosis, targeted therapy, bibliometric analysis, transforming growth factor β, and autotaxin inhibitor-capture the essential aspects of this research domain. This analysis serves as a reference point for future investigations into targeted therapies.
背景：特发性肺纤维化（IPF）是一种进行性、不可逆的间质性肺疾病，其特点是死亡率高。越来越多的证据强调了靶向治疗在IPF治疗中的关键作用。然而，对这一领域进行全面评估的文献计量学研究很少。本研究旨在探讨与IPF靶向治疗相关的全球文献生产和研究趋势。方法：检索Web of Science Core Collection中2004 - 2024年发表的文献，重点研究IPF的靶向治疗。文献计量学分析使用了VOSviewer、CiteSpace和r .的“bibliometrix”软件包等工具。结果：共纳入2779篇论文，表明随着时间的推移，论文数量呈持续增长的总体趋势。美国发表的论文最多，达到1052篇，法国的平均引用率最高，达到75.74篇。密歇根大学医学院（University of Michigan Medical School）发表论文88篇，是发表论文数量最多的大学。首席研究员Naftali Kaminski被认为是该领域最多产的研究者。发表论文最多的期刊是《美国呼吸细胞与分子生物学杂志》，共有98篇。近年来，围绕IPF靶向治疗的研究越来越多，特别是TGF-β、发病机制和autotaxin抑制剂等药物的研究。结论：通过文献计量学研究，我们系统分析了IPF靶向治疗的研究趋势，阐明了近期的研究前沿和新兴方向。选定的关键词-特发性肺纤维化，靶向治疗，文献计量学分析，转化生长因子β和自taxin抑制剂-捕获了该研究领域的基本方面。该分析可作为未来靶向治疗研究的参考点。
期刊介绍：
Frontiers in Medicine publishes rigorously peer-reviewed research linking basic research to clinical practice and patient care, as well as translating scientific advances into new therapies and diagnostic tools. Led by an outstanding Editorial Board of international experts, this multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
In addition to papers that provide a link between basic research and clinical practice, a particular emphasis is given to studies that are directly relevant to patient care. In this spirit, the journal publishes the latest research results and medical knowledge that facilitate the translation of scientific advances into new therapies or diagnostic tools. The full listing of the Specialty Sections represented by Frontiers in Medicine is as listed below. As well as the established medical disciplines, Frontiers in Medicine is launching new sections that together will facilitate
- the use of patient-reported outcomes under real world conditions
- the exploitation of big data and the use of novel information and communication tools in the assessment of new medicines
- the scientific bases for guidelines and decisions from regulatory authorities
- access to medicinal products and medical devices worldwide
- addressing the grand health challenges around the world
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