Shuteria involucrata alleviates OVA-induced asthma through the TLR4/NF-κB pathway

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-04-01 DOI:10.1016/j.fitote.2025.106520

Lue Bao , Lisha Wei , Xiaohong Li , Xiaoyun Jiang , Rong Duan , Lingrui Zhou , Lu Liu , Wenhong Tan , Feng Huang , Zhuya Yang

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引用次数: 0

Abstract

The roots of Shuteria involucrata (Wall.) Wight & Arn., known as “Tong-qian-ma-huang” in Dai folk medicine in China, are renowned for their efficacy in treating asthma. Despite the use of S. involucrata has been reported as ameliorating respiratory diseases, its mechanism of action remains unclear. This work described the effect of ethyl acetate extract of S. involucrate (SSE) on allergic asthma and its potential mechanism of action was assessed. Ovalbumin was used in vivo to establish a BALB/c asthma mouse model. Lipopolysaccharide was used in vitro to stimulate the human macrophage cell line THP-1 to establish an inflammatory model. In vivo and in vitro experiments showed that SSE effectively ameliorated pathological symptoms and attenuated airway inflammation and cellular inflammation in allergic asthma mice, with a mechanism of action potentially associated to the inhibition of the TLR4/NF-κB signaling pathway.

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天合疏蝇通过TLR4/NF-κB通路缓解ova诱导的哮喘。

珙桐的根（墙）wright & Arn。在中国傣族民间医学中被称为“通乾麻黄”，因其治疗哮喘的功效而闻名。尽管有报道称天山参可改善呼吸系统疾病，但其作用机制尚不清楚。本文介绍了山葵乙酸乙酯提取物对变应性哮喘的作用，并对其潜在的作用机制进行了评价。用卵清蛋白在体内建立BALB/c哮喘小鼠模型。采用脂多糖体外刺激人巨噬细胞THP-1建立炎症模型。体内和体外实验表明，SSE可有效改善变应性哮喘小鼠的病理症状，减轻气道炎症和细胞炎症，其作用机制可能与抑制TLR4/NF-κB信号通路有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.