Fulminant infective endocarditis with toxin-negative Corynebacterium diphtheriae in people with substance use experiencing homelessness, England, 2024 to 2025.

IF 9.9 2区医学 Q1 INFECTIOUS DISEASES

Eurosurveillance Pub Date : 2025-04-01 DOI:10.2807/1560-7917.ES.2025.30.13.2500148

Tara Patel, Tasnim Anwar, Eleni Mavrogiorgou, Natasa Utjesanovic, Anna Aryee, David J Litt, Joshua C D'Aeth, Christopher Primus, Satya Das, Nikolaos Karogiannis, Karthik Paranthaman, Gayatri Amirthalingam, Rebecca Cordery

引用次数: 0

Abstract

Between July 2024 and January 2025, five male patients in their early 20s to early 50s were confirmed with infective endocarditis associated with non-toxigenic Corynebacterium diphtheriae in England. Three were known to have experienced homelessness. All five used non-intravenous recreational drugs. Disease progression was rapid, four patients required surgical intervention, one died. Whole-genome sequencing and multilocus sequence type (MLST) analysis identified four individuals as ST559. Clinicians and substance use services have been alerted and enhanced surveillance implemented. A prevalence study is planned.

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暴发性感染性心内膜炎与毒素阴性白喉棒状杆菌的物质使用经历无家可归，英国，2024年至2025年。

在2024年7月至2025年1月期间，英国有5名20岁出头至50岁出头的男性患者被证实患有感染性心内膜炎，并伴有非产毒性白喉棒状杆菌。其中三人有过无家可归的经历。这五个人都使用非静脉注射毒品。病情进展迅速，4例患者需要手术治疗，1例死亡。全基因组测序和多位点序列型（MLST）分析鉴定4个个体为ST559。已向临床医生和药物使用服务机构发出警报，并实施了加强监测。计划进行一项流行病学研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Eurosurveillance INFECTIOUS DISEASES-

CiteScore

32.70

自引率

2.10%

发文量

430

审稿时长

3-8 weeks

期刊介绍： Eurosurveillance is a European peer-reviewed journal focusing on the epidemiology, surveillance, prevention, and control of communicable diseases relevant to Europe.It is a weekly online journal, with 50 issues per year published on Thursdays. The journal includes short rapid communications, in-depth research articles, surveillance reports, reviews, and perspective papers. It excels in timely publication of authoritative papers on ongoing outbreaks or other public health events. Under special circumstances when current events need to be urgently communicated to readers for rapid public health action, e-alerts can be released outside of the regular publishing schedule. Additionally, topical compilations and special issues may be provided in PDF format.