Epigenetic mechanisms in stem cell therapies for achilles tendinopathy.

IF 4.6 2区生物学 Q2 CELL BIOLOGY

Frontiers in Cell and Developmental Biology Pub Date : 2025-03-13 eCollection Date: 2025-01-01 DOI:10.3389/fcell.2025.1516250

Zheyang Yuan, Zheyu Yao, Xufeng Mao, Xiang Gao, Sengyi Wu, Haijiao Mao

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Abstract

Achilles tendinopathy (AT) is a chronic degenerative tendinopathy that affects people's daily lives. Multiple clinical studies have found that current conservative treatments fail to promote quality tendon healing. Recent studies have found that stem cell therapy can target pathophysiological changes in the tendon by replenishing tendon-derived cells, promoting extracellular matrix (ECM) remodeling, and modulating the inflammatory response to improve the microenvironment of Achilles tendon regeneration. And epigenetic modifications play an important role in stem cell fate determination and function. In this review, we provided a brief overview of the biological properties of relevant stem cells. The influence of epigenetic modifications on stem cell proliferation, differentiation, and immune regulatory function in the treatment of AT was also explored. We focused on gene regulatory mechanisms controlled by DNA methylation, histones and non-coding RNAs including microRNAs, circRNAs and long non-coding RNAs. We also discuss the current challenges faced by stem cell therapies in treating AT and their potential solutions. Further research in this area will provide a more comprehensive epigenetic explanation for stem cell therapy for AT, leading to the development of stable, safe and effective stem cell therapies.

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跟腱病干细胞治疗的表观遗传机制。

跟腱病（AT）是一种影响人们日常生活的慢性退行性肌腱病。多项临床研究发现，目前的保守治疗不能促进高质量的肌腱愈合。近期研究发现，干细胞治疗可通过补充肌腱源性细胞、促进细胞外基质（extracellular matrix， ECM）重塑、调节炎症反应等方式，靶向跟腱病理生理变化，改善跟腱再生微环境。表观遗传修饰在干细胞的命运和功能中起着重要的作用。在这篇综述中，我们简要介绍了相关干细胞的生物学特性。并探讨了表观遗传修饰对AT治疗中干细胞增殖、分化和免疫调节功能的影响。我们重点研究了DNA甲基化、组蛋白和非编码rna（包括microRNAs、circRNAs和长链非编码rna）控制的基因调控机制。我们还讨论了干细胞治疗AT所面临的挑战及其潜在的解决方案。该领域的进一步研究将为AT的干细胞治疗提供更全面的表观遗传学解释，从而开发稳定、安全、有效的干细胞治疗方法。

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来源期刊

Frontiers in Cell and Developmental Biology Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

9.70

自引率

3.60%

发文量

2531

审稿时长

12 weeks

期刊介绍： Frontiers in Cell and Developmental Biology is a broad-scope, interdisciplinary open-access journal, focusing on the fundamental processes of life, led by Prof Amanda Fisher and supported by a geographically diverse, high-quality editorial board. The journal welcomes submissions on a wide spectrum of cell and developmental biology, covering intracellular and extracellular dynamics, with sections focusing on signaling, adhesion, migration, cell death and survival and membrane trafficking. Additionally, the journal offers sections dedicated to the cutting edge of fundamental and translational research in molecular medicine and stem cell biology. With a collaborative, rigorous and transparent peer-review, the journal produces the highest scientific quality in both fundamental and applied research, and advanced article level metrics measure the real-time impact and influence of each publication.