Alveolar macrophages: guardians of the alveolar lipid galaxy.

IF 3.8 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Isaiah Little, Stephanie Bersie, Elizabeth F Redente, Alexandra L McCubbrey, Elizabeth J Tarling
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引用次数: 0

Abstract

Purpose of review: As the primary guardians at the air-surface interface, the functional profile of alveolar macrophages (AM) is wide-ranging from establishment of the alveolar niche, homeostatic maintenance of surfactant levels, to pathogen clearance and resolution and repair processes. Alveolar lipid homeostasis is disturbed in chronic lung diseases and contributes to disease pathogenesis through extracellular localization in the alveolar lumen or intracellular accumulation in AM. This review aims to provide a focused overview of the state of knowledge of AM, their ontogeny and development during health and disease, and how dysregulated AM lipids play a key role in disease processes, from initiation to resolution.

Recent findings: While lipid-laden macrophages are observed across a broad spectrum of lung diseases, their occurrence has largely been considered consequential. Recent advances in lipidomic profiling of single cell types has revealed that disturbances to lipid homeostasis occur early in disease in tissue-resident cells. Comparisons between inflammatory and fibrotic injury models reveal specific alveolar macrophage subsets with different lipid utilization that contribute to the disease process.

Summary: Understanding the intricate web of AM population seeding and development and how this niche is perturbed by lipid disturbances may help provide leverage for new interventions.

肺泡巨噬细胞:肺泡脂质星系的守护者。
综述目的:作为空气表面界面的主要守护者,肺泡巨噬细胞(AM)的功能范围广泛,从肺泡生态位的建立,表面活性剂水平的稳态维持,到病原体的清除、分解和修复过程。肺泡脂质稳态在慢性肺部疾病中受到干扰,并通过肺泡腔的细胞外定位或AM的细胞内积聚参与疾病的发病机制。这篇综述的目的是提供一个重点概述AM的知识状态,他们在健康和疾病中的个体发生和发展,以及失调的AM脂质如何在疾病过程中发挥关键作用,从开始到解决。最近的发现:虽然在广泛的肺部疾病中观察到脂质巨噬细胞,但它们的发生在很大程度上被认为是后果性的。单细胞类型脂质组学分析的最新进展表明,脂质稳态紊乱发生在疾病早期的组织驻留细胞中。炎症和纤维化损伤模型的比较揭示了具有不同脂质利用的特定肺泡巨噬细胞亚群在疾病过程中的作用。摘要:了解AM种群播种和发展的复杂网络,以及脂质干扰如何干扰这个生态位,可能有助于为新的干预措施提供杠杆作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current opinion in lipidology
Current opinion in lipidology 医学-内分泌学与代谢
CiteScore
6.70
自引率
4.50%
发文量
64
审稿时长
6-12 weeks
期刊介绍: With its easy-to-digest reviews on important advances in world literature, Current Opinion in Lipidology offers expert evaluation on a wide range of topics from six key disciplines including nutrition and metabolism, genetics and molecular biology, and hyperlipidaemia and cardiovascular disease. Published bimonthly, each issue covers in detail the most pertinent advances in these fields from the previous year. This is supplemented by a section of Bimonthly Updates, which deliver an insight into new developments at the cutting edge of the disciplines covered in the journal.
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