From Glucose Control to Multifaceted Benefits: The Rise of Modern Sulphonylureas in Diabetes Care.

IF 5.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Current Diabetes Reports Pub Date : 2025-04-04 DOI:10.1007/s11892-025-01582-6

Dina Shrestha, Atul Dhingra, Santosh Shakya, Jasmin Tuladhar

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引用次数: 0

Abstract

Purpose of review: This review aims to highlight the evolution and multifaceted benefits of modern sulfonylureas (SUs) in managing Type 2 Diabetes Mellitus (T2DM). It discusses their enhanced glycemic control, pleiotropic advantages, usage with other antidiabetic agents, safety, and tolerability, supporting their persistent relevance and effectiveness in diabetes care.

Recent findings: Recent findings indicate that modern SUs, like glimepiride, offer significant cardioprotective and renoprotective benefits along with their primary role in glycemic control. Additionally, they have also shown their anti-inflammatory effects, lipid-lowering properties, testosterone-enhancing effects, and neuroprotective effects in recent years. These findings support the broader therapeutic advantages of modern SUs beyond glucose lowering. Hence, many guidelines now recommend modern SUs as an add-on therapy to metformin. Modern sulfonylureas remain a vital component in T2DM management strategy due to their efficacy, safety profile, and cost-effectiveness. Their pleiotropic benefits, like cardiovascular, renal, anti-inflammatory, neuroprotective effects, etc., make them a comprehensive therapeutic option. Considering their efficacy and safety profile, SUs are expected to remain vital components of antidiabetic therapy, providing valuable benefits in managing T2DM in the long run.

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从血糖控制到多方面的益处：现代磺脲类药物在糖尿病治疗中的兴起。

综述目的：本综述旨在强调现代磺脲类药物（SUs）治疗2型糖尿病（T2DM）的发展和多方面益处。它讨论了它们增强血糖控制，多效性优势，与其他降糖药的使用，安全性和耐受性，支持它们在糖尿病治疗中的持续相关性和有效性。最近的发现：最近的发现表明，现代SUs，如格列美脲，除了在血糖控制方面的主要作用外，还具有显著的心脏保护和肾脏保护作用。此外，近年来它们还显示出抗炎作用、降脂作用、睾酮增强作用和神经保护作用。这些发现支持了现代SUs在降血糖之外的更广泛的治疗优势。因此，许多指南现在推荐现代SUs作为二甲双胍的附加治疗。由于其有效性、安全性和成本效益，现代磺脲类药物仍然是T2DM管理策略的重要组成部分。它们的多效性，如心血管、肾脏、抗炎、神经保护作用等，使它们成为综合治疗的选择。考虑到它们的有效性和安全性，单磺酸钠有望成为抗糖尿病治疗的重要组成部分，在长期治疗T2DM方面提供有价值的益处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Diabetes Reports 医学 -

CiteScore

9.80

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The goal of this journal is to publish cutting-edge reviews on subjects pertinent to all aspects of diabetes epidemiology, pathophysiology, and management. We aim to provide incisive, insightful, and balanced contributions from leading experts in each relevant domain that will be of immediate interest to a wide readership of clinicians, basic scientists, and translational investigators. We accomplish this aim by appointing major authorities to serve as Section Editors in key subject areas across the discipline. Section Editors select topics to be reviewed by leading experts who emphasize recent developments and highlight important papers published over the past year on their topics, in a crisp and readable format. We also provide commentaries from well-known figures in the field, and an Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.