Photoswitchable phospholipids for the optical control of membrane processes, protein function, and drug delivery.

IF 7.5 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Communications Materials Pub Date : 2025-01-01 Epub Date: 2025-04-01 DOI:10.1038/s43246-025-00773-8

Stefanie D Pritzl, Johannes Morstein, Nikolaj A Pritzl, Jan Lipfert, Theobald Lohmüller, Dirk H Trauner

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Abstract

Recent insights into the function and composition of cell membranes have transformed our understanding from primarily viewing these structures as passive barriers to recognizing them as dynamic entities actively involved in many cellular functions. This review highlights advances in the photopharmacology of phospholipids, emphasizing in particular the role of diacylglycerophospholipids and the impact of their polymorphic nature on synthetic and cellular membrane properties and metabolic processes. We explore photoswitchable diacylglycerophospholipids, termed 'photolipids', which permit precise, reversible modifications of membrane properties via light-induced isomerization. The ability to optically switch phospholipid properties has potential applications in controlling membrane dynamics, protein function, and cellular signaling pathways, and offers promising strategies for drug delivery and treatment of diseases. Developments in azobenzene and hemithioindigo based photolipids are discussed, underscoring their utility in biomedical and biomaterial science applications due to their unique photophysical properties.

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光开关磷脂用于膜过程、蛋白质功能和药物传递的光学控制。

最近对细胞膜功能和组成的深入研究使我们的理解从最初将这些结构视为被动屏障转变为将它们视为积极参与许多细胞功能的动态实体。本文综述了磷脂的光药理学研究进展，特别强调了二酰基甘油磷脂的作用及其多态性对合成和细胞膜特性以及代谢过程的影响。我们探索可光切换的二酰基甘油磷脂，称为“光脂”，它允许通过光诱导异构化对膜性质进行精确、可逆的修饰。光开关磷脂性质的能力在控制膜动力学、蛋白质功能和细胞信号通路方面具有潜在的应用，并为药物传递和疾病治疗提供了有前途的策略。讨论了偶氮苯和半硫靛蓝基光脂的发展，强调了它们在生物医学和生物材料科学中的应用，因为它们具有独特的光物理性质。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Communications Materials MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

12.10

自引率

1.30%

发文量

审稿时长

17 weeks

期刊介绍： Communications Materials, a selective open access journal within Nature Portfolio, is dedicated to publishing top-tier research, reviews, and commentary across all facets of materials science. The journal showcases significant advancements in specialized research areas, encompassing both fundamental and applied studies. Serving as an open access option for materials sciences, Communications Materials applies less stringent criteria for impact and significance compared to Nature-branded journals, including Nature Communications.