CMR Findings in the Long-Term Outcomes After Multisystem Inflammatory Syndrome in Children (MUSIC) Study.

IF 6.5 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Circulation: Cardiovascular Imaging Pub Date : 2025-04-04 DOI:10.1161/CIRCIMAGING.124.017420

Sean M Lang, Dongngan T Truong, Andrew J Powell, Valiantsina Kazlova, Jane W Newburger, Jordan D Awerbach, Edem Binka, Tamara T Bradford, Mark Cartoski, Andrew Cheng, Michael P DiLorenzo, Audrey Dionne, Adam L Dorfman, Matthew D Elias, Olukayode Garuba, Jennifer F Gerardin, Keren Hasbani, Pei-Ni Jone, Christopher Z Lam, Nilanjana Misra, Lerraughn M Morgan, Arni Nutting, Jyoti K Patel, Joshua D Robinson, Eleanor L Schuchardt, Kristen Sexson Tejtel, Gautam K Singh, Timothy C Slesnick, Felicia Trachtenberg, Michael D Taylor

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引用次数: 0

Abstract

Background: Multisystem Inflammatory Syndrome in Children is characterized by high rates of acute cardiovascular involvement with rapid recovery of organ dysfunction. However, information regarding long-term sequelae is lacking. We sought to characterize the systolic function and myocardial tissue properties using cardiac magnetic resonance (CMR) imaging in a multicenter observational cohort of Multisystem Inflammatory Syndrome in Children patients.

Methods: In this observational cohort study, comprising 32 centers in North America, CMR studies were analyzed by a core laboratory to assess ventricular volumetric data, tissue characterization, and coronary involvement.

Results: A total of 263 CMRs from 255 Multisystem Inflammatory Syndrome in Children patients were analyzed. The mean patient age was 11.4±4.4 years. Most studies were performed at 3 months (33%) or 6 months (45%) after hospitalization. Left ventricular dysfunction was present in 17 (6.7%) of the first CMRs and was never worse than mild. Dysfunction was observed in 4/7 (57%) patients at admission, 5/87 (6.9%) patients at 3 months, and 6/129 (4.6%) patients imaged either at 6 months or 1 year post-hospitalization. Late gadolinium enhancement was present in 2 (0.8%) patients, 1 at 3 months and another at 6 months following hospitalization. Coronary artery dilation was present in 13 of the 174 (7.5%) patients. Nine patients met the Lake Louise criteria for myocarditis (3.5%) at the time of CMR.

Conclusions: In this largest published multiinstitutional longitudinal CMR evaluation of confirmed Multisystem Inflammatory Syndrome in Children patients, the prevalence of ventricular dysfunction and myocardial tissue characterization abnormalities on medium-term follow-up was low. However, a small number of patients had mild residual abnormalities at 6 months and 1 year following hospitalization.

Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT05287412.

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儿童多系统炎症综合征（MUSIC）研究后长期预后的CMR结果。

背景：儿童多系统炎症综合征的特点是急性心血管受累率高，器官功能障碍恢复迅速。然而，缺乏关于长期后遗症的信息。我们试图利用心脏磁共振（CMR）成像在儿童多系统炎症综合征患者的多中心观察队列中表征收缩功能和心肌组织特性。方法：在这项包括北美32个中心的观察性队列研究中，CMR研究由一个核心实验室进行分析，以评估心室容量数据、组织特征和冠状动脉受累情况。结果：对255例儿童多系统炎症综合征患者263例cmr进行了分析。患者平均年龄11.4±4.4岁。大多数研究是在住院后3个月（33%）或6个月（45%）进行的。首次cmr患者中有17例（6.7%）出现左心室功能不全，病情不严重。入院时4/7（57%）患者出现功能障碍，3个月时5/87（6.9%）患者出现功能障碍，6/129（4.6%）患者在住院后6个月或1年成像。2例（0.8%）患者出现晚期钆增强，1例在住院后3个月，另1例在住院后6个月。174例患者中有13例（7.5%）出现冠状动脉扩张。9例患者在CMR时符合Lake Louise心肌炎标准（3.5%）。结论：在这项已发表的最大规模的多机构纵向CMR评估中，确诊的儿童多系统炎症综合征患者在中期随访中出现心室功能障碍和心肌组织特征异常的发生率较低。然而，少数患者在住院后6个月和1年有轻度残留异常。注册：网址：https://www.clinicaltrials.gov；唯一标识符：NCT05287412。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Circulation: Cardiovascular Imaging 医学-核医学

CiteScore

6.30

自引率

2.70%

发文量

225

审稿时长

6-12 weeks

期刊介绍： Circulation: Cardiovascular Imaging, an American Heart Association journal, publishes high-quality, patient-centric articles focusing on observational studies, clinical trials, and advances in applied (translational) research. The journal features innovative, multimodality approaches to the diagnosis and risk stratification of cardiovascular disease. Modalities covered include echocardiography, cardiac computed tomography, cardiac magnetic resonance imaging and spectroscopy, magnetic resonance angiography, cardiac positron emission tomography, noninvasive assessment of vascular and endothelial function, radionuclide imaging, molecular imaging, and others. Article types considered by Circulation: Cardiovascular Imaging include Original Research, Research Letters, Advances in Cardiovascular Imaging, Clinical Implications of Molecular Imaging Research, How to Use Imaging, Translating Novel Imaging Technologies into Clinical Applications, and Cardiovascular Images.