Intestinal-region-specific functions of AHR in intrinsic enteric neurons during infections.

IF 7.5 1区生物学 Q1 CELL BIOLOGY

Cell reports Pub Date : 2025-04-22 Epub Date: 2025-04-01 DOI:10.1016/j.celrep.2025.115524

Zijia Sun, Yingsheng Wang, Shaorui Liu, Hui Li, Danyang He, Heping Xu

引用次数: 0

Abstract

Intrinsic enteric neurons (iENs) form a crucial neuronal network within the myenteric and submucosal plexus of the gastrointestinal tract, primarily responsible for regulating gut peristalsis. The mechanisms by which iENs sense and integrate dietary and microbial signals to regulate intestinal homeostasis and inflammation remain unclear. Here, we showed that environmental sensor aryl hydrocarbon receptor (AHR) was expressed in different iEN subsets in the ileum and colon and that AHR ligands differentially modulated iEN activity in these regions. Genetic perturbation of Ahr in neurons increased iEN activation in the ileum but, conversely, decreased it in the colon in response to different intestinal pathogens. Furthermore, neuronal AHR deficiency enhanced the clearance of bacterial pathogens, which was associated with increased proliferation and abundance of group 3 innate lymphoid cells in the ileum. Together, our findings demonstrate the region-specific functions of AHR in neurons in response to infections.

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感染期间AHR在肠道内神经元中的肠道区域特异性功能。

内在肠神经元（iENs）在胃肠道的肌肠和粘膜下神经丛中形成一个重要的神经网络，主要负责调节肠道蠕动。iENs感知和整合饮食和微生物信号以调节肠道内稳态和炎症的机制尚不清楚。在这里，我们发现环境传感器芳烃受体（AHR）在回肠和结肠的不同iEN亚群中表达，并且AHR配体对这些区域的iEN活性有差异调节。神经元中Ahr的遗传扰动增加了回肠中iEN的激活，但相反地，在不同的肠道病原体的作用下，降低了结肠中的iEN激活。此外，神经元AHR缺陷增强了对细菌病原体的清除，这与回肠中第3组先天淋巴样细胞的增殖和丰度增加有关。总之，我们的发现证明了AHR在神经元对感染的反应中具有区域特异性功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell reports CELL BIOLOGY-

CiteScore

13.80

自引率

1.10%

发文量

1305

审稿时长

77 days

期刊介绍： Cell Reports publishes high-quality research across the life sciences and focuses on new biological insight as its primary criterion for publication. The journal offers three primary article types: Reports, which are shorter single-point articles, research articles, which are longer and provide deeper mechanistic insights, and resources, which highlight significant technical advances or major informational datasets that contribute to biological advances. Reviews covering recent literature in emerging and active fields are also accepted. The Cell Reports Portfolio includes gold open-access journals that cover life, medical, and physical sciences, and its mission is to make cutting-edge research and methodologies available to a wide readership. The journal's professional in-house editors work closely with authors, reviewers, and the scientific advisory board, which consists of current and future leaders in their respective fields. The advisory board guides the scope, content, and quality of the journal, but editorial decisions are independently made by the in-house scientific editors of Cell Reports.