Modulating immune responses in alopecia: therapeutic insights and potential targets of antisense oligonucleotides.

IF 2.9 4区 医学 Q3 IMMUNOLOGY
Shahnaz Begum, Md Jamil Hossain, Insun Kim, Hyun Su Min, Yu Na Lim, Hyun-Jeong Cho, Jin-Hyeob Ryu
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引用次数: 0

Abstract

Background: Alopecia areata (AA) are hair loss disorders with distinct pathogenetic mechanisms involving immune dysregulation and microRNA modulation. AA, a T cell-mediated autoimmune disease, is characterized by sudden hair loss, with interferon-gamma (IFN-γ) playing a pivotal role in pathogenesis. The upregulation of IFN response genes, including IFN-inducible chemokines CXCL9, CXCL10, and CXCL11, in lesional skin reflects the activation of the IFN response pathway and contributes to immune cell recruitment and inflammation.

Results: Recent research highlights the role of SIRT1, a class III histone deacetylase, in modulating immune responses in AA. SIRT1 inhibition promotes the production of Th1 cytokines and chemokines, impairing inflammation, while SIRT1 activation suppresses autoreactive responses through NF-κB deacetylation and STAT3 phosphorylation. Additionally, antisense oligonucleotides (ASOs) targeting miR-485-3p show therapeutic potential in promoting hair regrowth and mitigating inflammation in murine models of androgenic alopecia (AGA) and AA.

Conclusion: Understanding chemokine dysregulation provides key insights into AA pathogenesis and highlights TAMI-M as a potential therapy for reducing inflammation and promoting hair regeneration. These findings advance the exploration of immune, microRNA, and SIRT1 pathways as targets for novel hair loss treatments.

调节脱发的免疫反应:反义寡核苷酸的治疗见解和潜在靶点。
背景:斑秃是一种具有不同发病机制的脱发疾病,涉及免疫失调和microRNA的调节。AA是一种T细胞介导的自身免疫性疾病,以突发性脱发为特征,干扰素-γ (IFN-γ)在其发病机制中起关键作用。IFN反应基因(包括IFN诱导的趋化因子CXCL9、CXCL10和CXCL11)在病变皮肤中的上调反映了IFN反应途径的激活,并有助于免疫细胞募集和炎症。结果:最近的研究强调了SIRT1 (III类组蛋白去乙酰化酶)在调节AA免疫反应中的作用。SIRT1抑制促进Th1细胞因子和趋化因子的产生,损害炎症,而SIRT1激活通过NF-κB去乙酰化和STAT3磷酸化抑制自身反应反应。此外,靶向miR-485-3p的反义寡核苷酸(ASOs)在雄激素性脱发(AGA)和AA小鼠模型中显示出促进头发再生和减轻炎症的治疗潜力。结论:了解趋化因子失调为了解AA的发病机制提供了关键的见解,并突出了TAMI-M作为减少炎症和促进头发再生的潜在治疗方法。这些发现推动了对免疫、microRNA和SIRT1途径作为新型脱发治疗靶点的探索。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BMC Immunology
BMC Immunology 医学-免疫学
CiteScore
5.50
自引率
0.00%
发文量
54
审稿时长
1 months
期刊介绍: BMC Immunology is an open access journal publishing original peer-reviewed research articles in molecular, cellular, tissue-level, organismal, functional, and developmental aspects of the immune system as well as clinical studies and animal models of human diseases.
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