Immunomodulators for Steroid-Dependent Recurrent Acute Pancreatitis After Immune Checkpoint Inhibitor Therapy: A Case Series.

IF 0.6 Q4 GASTROENTEROLOGY & HEPATOLOGY

ACG Case Reports Journal Pub Date : 2025-04-03 eCollection Date: 2025-04-01 DOI:10.14309/crj.0000000000001653

Hannah Peck, Wilfredo Pagani, Arianna Smith, Srivats Madhavan

引用次数: 0

Abstract

One to 2% of patients undergoing immune checkpoint inhibitor (ICI) therapy develop ICI-induced pancreatitis (ICI-IP). A small subset of these patients develop recurrent pancreatitis, even after discontinuation of ICI therapy. This case series presents 2 patients with recurrent steroid-responsive ICI-IP who were managed with immunomodulators as steroid-sparing agents. Both patients were maintained on immunomodulators for approximately 2 years before discontinuation of the agents, with no further recurrence or complications of pancreatitis. This case series highlights the use of mycophenolate mofetil and azathioprine for the management of recurrent ICI-IP.

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免疫检查点抑制剂治疗后类固醇依赖性复发性急性胰腺炎的免疫调节剂：一个病例系列。

在接受免疫检查点抑制剂（ICI）治疗的患者中，有1%到2%的患者会出现ICI诱发的胰腺炎（ICI-IP）。其中一小部分患者即使在停止 ICI 治疗后仍会复发胰腺炎。本系列病例介绍了 2 例复发性类固醇反应性 ICI-IP 患者，他们均使用免疫调节剂作为类固醇备用药物进行治疗。这两名患者在停用免疫调节剂约 2 年后，均未再复发或出现胰腺炎并发症。本系列病例强调了使用霉酚酸酯和硫唑嘌呤治疗复发性 ICI-IP 的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACG Case Reports Journal GASTROENTEROLOGY & HEPATOLOGY-

自引率

14.30%

发文量

170

审稿时长

12 weeks

期刊介绍： ACG Case Reports Journal is a peer-reviewed, open-access publication that provides GI and hepatology fellows, private practice clinicians, and other healthcare providers an opportunity to share interesting case reports with their peers and with leaders in the field. ACG Case Reports Journal publishes case reports, images, videos and letters to the editor in all topics of gastroenterology and hepatology, including: Biliary Colon Endoscopy Esophagus Functional Bowel Disorders Inflammatory Bowel Disease Liver Nutrition and Obesity Pancreas Pathology Pediatric Small Bowel Stomach.