Guoliang Zheng, Bao Zhang, Haiyue Yu, Zhiyong Song, Xing Xu, Zhichao Zheng, Kui Zhao, Jian Zhao, Yan Zhao
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引用次数: 0
Abstract
In the last 2 decades, nanomedicine has gained enormous attention due to its promising potential in various biomedical applications such as targeted drug delivery, molecular imaging, biomarker mapping, and diagnosis. Owing to their low toxicity, and longer half-life, several nano-delivery systems such as nanoparticles, lipid carriers, dendrimers, liposomes, and micelles have been developed with unique functions and properties. With benefits such as size variability, good drug loading capacity, stable interactions, and binding with both hydrophobic and hydrophilic substances, nano-delivery systems are designed to overcome problems that are associated with conventional therapies. In the context of gastrointestinal disorders, nano-drug delivery systems are effective in improving drug efficacy, bioavailability, and sustained drug release with minimal side effects. Despite all these technological advancements, nano-delivery systems encounter potential biological barriers in the form of enzymatic degradation, pH variability, and other barriers that hinder the smooth operations of the delivery process. Targeted delivery to specific receptors, passive accumulation of nanoparticles, and pH-sensitive drug release systems are the counter strategies that researchers have been using. This overview explores the role of nano-delivery systems in the treatment of gastrointestinal disorders, focusing on their therapeutic applications and the biological barriers that may limit their efficacy. Additionally, it summarizes the current research landscape and discusses the future prospects for advancing nano-delivery technologies in the management of gastrointestinal diseases.
期刊介绍：
Advanced Composites and Hybrid Materials is a leading international journal that promotes interdisciplinary collaboration among materials scientists, engineers, chemists, biologists, and physicists working on composites, including nanocomposites. Our aim is to facilitate rapid scientific communication in this field.
The journal publishes high-quality research on various aspects of composite materials, including materials design, surface and interface science/engineering, manufacturing, structure control, property design, device fabrication, and other applications. We also welcome simulation and modeling studies that are relevant to composites. Additionally, papers focusing on the relationship between fillers and the matrix are of particular interest.
Our scope includes polymer, metal, and ceramic matrices, with a special emphasis on reviews and meta-analyses related to materials selection. We cover a wide range of topics, including transport properties, strategies for controlling interfaces and composition distribution, bottom-up assembly of nanocomposites, highly porous and high-density composites, electronic structure design, materials synergisms, and thermoelectric materials.
Advanced Composites and Hybrid Materials follows a rigorous single-blind peer-review process to ensure the quality and integrity of the published work.
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