The miRNomics of antiretroviral therapy-induced obesity

IF 3.9 4区生物学 Q1 GENETICS & HEREDITY

Functional & Integrative Genomics Pub Date : 2025-04-05 DOI:10.1007/s10142-025-01585-2

Niska Majumdar, Bishwa R. Pokharel, Abigail Dickerson, Andreea Cruceanu, Smit Rajput, Lok R. Pokhrel, Paul P. Cook, Shaw M. Akula

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引用次数: 0

Abstract

Human immunodeficiency virus (HIV) is a retrovirus that incorporates its genetic material into the host’s chromosome. The resulting diseases and related conditions constitute a global health problem as there are no treatments to eliminate HIV from an infected individual. However, the potent, complex, and active antiretroviral therapy (ART) strategies have been able to successfully inhibit HIV replication in patients. Unfortunately, obesity following ART is frequent among HIV-infected patients. The mechanism underlying ART-induced obesity is characterized based on expression of traditional markers such as genes and proteins. However, little is known about, yet another key component of molecular biology known as microRNAs (miRNAs). Micro-RNAs are ~ 22 base-long non-coding nucleotides capable of regulating more than 60% of all human protein-coding genes. The interest in miRNA molecules is increasing and their roles in HIV and obesity are beginning to be apparent. In this review, we provide an overview of HIV and its associated diseases, ART-induced obesity, and discuss the roles and plausible benefits of miRNAs in regulating obesity genes in HIV-infected patients. Understanding the roles of miRNAs in ART-induced obesity will aid in tracking the disease progression and designing beneficial therapeutic approaches.

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抗逆转录病毒疗法诱发肥胖的 miRNomics

人类免疫缺陷病毒（HIV）是一种将其遗传物质整合到宿主染色体中的逆转录病毒。由此产生的疾病和相关病症构成了一个全球健康问题，因为没有任何治疗方法可以消除受感染者体内的艾滋病毒。然而，有效、复杂和有效的抗逆转录病毒治疗（ART）策略已经能够成功地抑制患者体内的HIV复制。不幸的是，抗逆转录病毒治疗后的肥胖在艾滋病毒感染者中很常见。art诱导肥胖的机制是基于基因和蛋白质等传统标记的表达来表征的。然而，我们对分子生物学的另一个关键组成部分——microrna （miRNAs）知之甚少。微rna是约22个碱基长的非编码核苷酸，能够调节60%以上的人类蛋白质编码基因。对miRNA分子的兴趣正在增加，它们在HIV和肥胖中的作用开始显现。在这篇综述中，我们概述了HIV及其相关疾病、art诱导的肥胖，并讨论了mirna在调节HIV感染患者肥胖基因中的作用和可能的益处。了解mirna在art诱导的肥胖中的作用将有助于跟踪疾病进展和设计有益的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Functional & Integrative Genomics 生物-遗传学

CiteScore

3.50

自引率

3.40%

发文量

审稿时长

2 months

期刊介绍： Functional & Integrative Genomics is devoted to large-scale studies of genomes and their functions, including systems analyses of biological processes. The journal will provide the research community an integrated platform where researchers can share, review and discuss their findings on important biological questions that will ultimately enable us to answer the fundamental question: How do genomes work?