Reassessing the role of amyloid in isolated REM sleep behavior disorder

IF 3.1 3区医学 Q2 CLINICAL NEUROLOGY

Parkinsonism & related disorders Pub Date : 2025-03-27 DOI:10.1016/j.parkreldis.2025.107809

Qiu-Han Xu, Cheng Wang

引用次数: 0

Abstract

We investigated the causal relationship between cortical amyloid-β (Aβ) deposition, isolated REM sleep behavior disorder (iRBD), and Lewy body dementia (LBD) using Mendelian randomization (MR) analysis. Our findings revealed no causal link between Aβ deposition and iRBD/LBD, suggesting amyloid accumulation in iRBD is likely a coexisting phenomenon rather than a primary driver of disease progression.

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来源期刊

Parkinsonism & related disorders 医学-临床神经学

CiteScore

6.20

自引率

4.90%

发文量

292

审稿时长

39 days

期刊介绍： Parkinsonism & Related Disorders publishes the results of basic and clinical research contributing to the understanding, diagnosis and treatment of all neurodegenerative syndromes in which Parkinsonism, Essential Tremor or related movement disorders may be a feature. Regular features will include: Review Articles, Point of View articles, Full-length Articles, Short Communications, Case Reports and Letter to the Editor.