Microneedles-based technology as an innovative strategy for alleviating neurological disorders – Current progress and future perspectives

IF 4.5 3区医学 Q1 PHARMACOLOGY & PHARMACY

Journal of Drug Delivery Science and Technology Pub Date : 2025-04-01 DOI:10.1016/j.jddst.2025.106890

Sathyaraj Weslen Vedakumari , Lokesh Prabakaran , Yovan Raja Pravin

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Abstract

Neurological diseases serve as the second major cause of death among the global population. Complicated treatment procedures, specialized care with skilled technician, constant access to physician and numerous diagnostic practices are required to manage neurological diseases. Intradermal, intravenous and intramuscular modes of drug administration are the common routes of drug delivery. Administering drugs to central nervous system (CNS) is highly complicated due to different barriers such as blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier (BCSFB). Discovering innovative treatment strategies for alleviating neurological disorders serves as a major concern for clinical research. Currently, microneedles (MNs) have gained huge attention owing to their biocompatible, non-invasive and painless method of transdermal drug delivery. This review article highlights the potential use and recent progress in MNs-based technology for treating neurological diseases.

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来源期刊

Journal of Drug Delivery Science and Technology 医学-药学

CiteScore

8.00

自引率

8.00%

发文量

879

审稿时长

94 days

期刊介绍： The Journal of Drug Delivery Science and Technology is an international journal devoted to drug delivery and pharmaceutical technology. The journal covers all innovative aspects of all pharmaceutical dosage forms and the most advanced research on controlled release, bioavailability and drug absorption, nanomedicines, gene delivery, tissue engineering, etc. Hot topics, related to manufacturing processes and quality control, are also welcomed.