Resveratrol interrupts Wnt/β-catenin signalling in cervical cancer by activating ten-eleven translocation 5-methylcytosine dioxygenase 1

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cytokine Pub Date : 2025-04-05 DOI:10.1016/j.cyto.2025.156930

Ji Ren , Luhong Xie , Xiaoyu Zhu , Xiuying Chen , Lin Wei , Dianqin Xu , Kun Qiao , Shaoju Min , Yan Ding , Yujie Tan

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Abstract

Epigenetic modification can be a key weapon employed by both sides of the battle between Cervical Cancer progression due to persistent high-risk papillomavirus (hr-HPV) infection and the development of anti-cancer modalities. Alongside the overactivated Wnt/β-catenin activity, reduced TET1 expression and ratio of 5-hydroxymethylcytosine (5hmC) to 5-methylcytosine (5mC) were found in cervical cancer, which was correlated with lymph node metastasis. After treating cervical cancer cells with Resveratrol (RES), we found that TET1 expression was elevated and Wnt/β-catenin pathway activity was suppressed. Therefore, the aim of this study is to investigate the influence of resveratrol on the TET1 and Wnt/β-catenin pathways, and to elucidate the molecular mechanisms involved in this process, thereby clarifying the potential value of RES in the treatment of cervical cancer. Our data illustrate the TET1-mediated epigenetic modulation was an integral part of the effects of RES on the Wnt/β-catenin pathway in cervical cancer.

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白藜芦醇通过激活10 - 11易位5-甲基胞嘧啶双加氧酶1阻断宫颈癌中Wnt/β-catenin信号传导

表观遗传修饰可以成为宫颈癌由于持续的高风险乳头瘤病毒（hr-HPV）感染而进展和抗癌模式发展之间的战斗双方使用的关键武器。在Wnt/β-catenin活性过度激活的同时，宫颈癌中TET1的表达和5-羟甲基胞嘧啶(5hmC) / 5-甲基胞嘧啶（5mC）的比值降低，与淋巴结转移相关。用白藜芦醇（Resveratrol， RES）治疗宫颈癌细胞后，我们发现TET1表达升高，Wnt/β-catenin通路活性被抑制。因此，本研究的目的是探讨白藜芦醇对TET1和Wnt/β-catenin通路的影响，并阐明其参与这一过程的分子机制，从而阐明RES在宫颈癌治疗中的潜在价值。我们的数据表明，tet1介导的表观遗传调控是RES对宫颈癌Wnt/β-catenin通路影响的一个组成部分。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytokine 医学-免疫学

CiteScore

7.60

自引率

2.60%

发文量

262

审稿时长

48 days

期刊介绍： The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.