Electrochemical biosensors for early detection of Alzheimer’s disease

IF 3.2 3区医学 Q2 MEDICAL LABORATORY TECHNOLOGY

Clinica Chimica Acta Pub Date : 2025-04-02 DOI:10.1016/j.cca.2025.120278

Sanoeva Matlyuba Jakhonkulovna , Gulnoz Bahodirova Kamolovna , Muzaffar Zokirov , Babajanova Umida Tajimuratovna , Alexey Yumashev , Rustem Shichiyakh , Nasiba I. Safarova , Aripova Nargiza Nusratovna , Nilufar Esanmuradova , Tadjibaeva Muyassar Karimbaevna , Alidjanova Lazizakhon , Alisher Ishankulov

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引用次数: 0

Abstract

In recent years, electrochemical biosensors have shown great promise as innovative tools for the early identification of Alzheimer’s disease (AD), a neurodegenerative disorder that severely affects cognitive ability and overall quality of life. This comprehensive review aims to consolidate the latest research on the creation and implementation of electrochemical biosensors designed to detect AD-related biomarkers. We examine cutting-edge approaches to surface modification that enhance the attachment of biorecognition molecules, thus enabling the simultaneous identification of multiple biomarkers. This review emphasizes the crucial role that electrochemical biosensors play in the early diagnosis of Alzheimer’s disease, highlighting their potential to revolutionize clinical practices by facilitating timely interventions. In the future, research efforts should concentrate on refining these technologies for widespread clinical adoption, ensuring that they meet the needs of both healthcare professionals and patients.

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用于阿尔茨海默病早期检测的电化学生物传感器

阿尔茨海默病（AD）是一种严重影响认知能力和整体生活质量的神经退行性疾病。本综述旨在整合有关创建和实施电化学生物传感器的最新研究成果，以检测与阿尔茨海默病相关的生物标记物。我们探讨了表面修饰的前沿方法，这些方法可增强生物识别分子的附着力，从而实现对多种生物标志物的同时识别。这篇综述强调了电化学生物传感器在阿尔茨海默病早期诊断中的关键作用，突出了它们通过促进及时干预而彻底改变临床实践的潜力。今后，研究工作应集中于完善这些技术，以便在临床上广泛采用，确保它们能满足医护人员和患者的需求。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinica Chimica Acta 医学-医学实验技术

CiteScore

10.10

自引率

2.00%

发文量

1268

审稿时长

23 days

期刊介绍： The Official Journal of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Clinica Chimica Acta is a high-quality journal which publishes original Research Communications in the field of clinical chemistry and laboratory medicine, defined as the diagnostic application of chemistry, biochemistry, immunochemistry, biochemical aspects of hematology, toxicology, and molecular biology to the study of human disease in body fluids and cells. The objective of the journal is to publish novel information leading to a better understanding of biological mechanisms of human diseases, their prevention, diagnosis, and patient management. Reports of an applied clinical character are also welcome. Papers concerned with normal metabolic processes or with constituents of normal cells or body fluids, such as reports of experimental or clinical studies in animals, are only considered when they are clearly and directly relevant to human disease. Evaluation of commercial products have a low priority for publication, unless they are novel or represent a technological breakthrough. Studies dealing with effects of drugs and natural products and studies dealing with the redox status in various diseases are not within the journal''s scope. Development and evaluation of novel analytical methodologies where applicable to diagnostic clinical chemistry and laboratory medicine, including point-of-care testing, and topics on laboratory management and informatics will also be considered. Studies focused on emerging diagnostic technologies and (big) data analysis procedures including digitalization, mobile Health, and artificial Intelligence applied to Laboratory Medicine are also of interest.