Ovarian metastasis from lobular breast carcinoma: A case report with review of literature

Q4 Medicine

Radiology Case Reports Pub Date : 2025-04-05 DOI:10.1016/j.radcr.2025.03.043

Yasameen M. Mohammed , Zuhair D. Hammood , Abdulwahid M. Salih , Hadeel A. Yasseen , Soran H. Tahir , Sami S. Omar , Rebaz Haji Ali , Rawa M. Ali , Belan Mikaeil M. Radha , Ayman M. Mustafa , Fahmi H. Kakamad

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引用次数: 0

Abstract

Although breast cancer can metastasize to various sites, involvement of the ovaries is infrequent. The current study aims to report a case of ovarian cancer originating from the breast along with an in-depth analysis of the literature. A 58-year-old woman with a history of invasive lobular carcinoma underwent surgery followed by adjuvant chemo-radiotherapy. During regular follow-up, a suspicious ovarian mass was detected, later confirmed to be metastasis from the breast cancer. A review of 25 studies on Google Scholar and PubMed identified 7185 ovarian metastasis patients, with 1253 cases originating from breast cancer, accounting for approximately 17.4% of all metastatic ovarian cancers. Bilateral ovarian involvement was noted in 75% of cases, with right-side involvement in 5.7% and left-side in 19.3%. Only 13 studies documented menopausal status, showing 53.6% were premenopausal. Controversies persist in distinguishing primary ovarian cancer from metastasis using clinical signs, serum markers, and imaging. Metastasis of breast cancer to the ovaries is an uncommon event, even after utilizing various therapeutic approaches. Surgery is the treatment of choice for these cases. This case highlights the importance of long-term surveillance in breast cancer patients and emphasizes the role of surgery in managing ovarian metastases.

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小叶型乳腺癌卵巢转移1例并文献复习

尽管乳腺癌可转移至不同部位，但累及卵巢的情况并不多见。本研究旨在报告一例源于乳腺癌的卵巢癌病例，并对相关文献进行深入分析。一名 58 岁的女性患者曾患浸润性小叶癌，接受手术后进行了辅助化疗和放疗。在定期随访期间，发现了一个可疑的卵巢肿块，后证实为乳腺癌转移。谷歌学者和PubMed上的25项研究发现，7185例卵巢转移患者中有1253例来自乳腺癌，约占所有转移性卵巢癌的17.4%。75%的病例为双侧卵巢受累，5.7%为右侧受累，19.3%为左侧受累。只有13项研究记录了绝经状态，其中53.6%为绝经前状态。在利用临床症状、血清标记物和影像学来区分原发性卵巢癌和转移瘤方面仍存在争议。即使采用了各种治疗方法，乳腺癌转移到卵巢的情况也不常见。手术是此类病例的首选治疗方法。本病例突出了对乳腺癌患者进行长期监测的重要性，并强调了手术在治疗卵巢转移中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Radiology Case Reports Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

1.10

自引率

0.00%

发文量

1074

审稿时长

30 days

期刊介绍： The content of this journal is exclusively case reports that feature diagnostic imaging. Categories in which case reports can be placed include the musculoskeletal system, spine, central nervous system, head and neck, cardiovascular, chest, gastrointestinal, genitourinary, multisystem, pediatric, emergency, women''s imaging, oncologic, normal variants, medical devices, foreign bodies, interventional radiology, nuclear medicine, molecular imaging, ultrasonography, imaging artifacts, forensic, anthropological, and medical-legal. Articles must be well-documented and include a review of the appropriate literature.