Smart polymer prodrugs via responsive prodrug-initiated ring-opening polymerization of lactide for improved drug delivery†

IF 5.1 3区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nanoscale Pub Date : 2025-04-04 DOI:10.1039/D5NR00780A

Shiwei Fu, Miao Zhang, Nicholas Calzadilla, Bowen Zhao, Xiao Zhang, Bowei Yang, Victoria A. A. McKenzie, Ajay Zheng, Qianqian Ni and Fuwu Zhang

引用次数: 0

Abstract

Smart polymer prodrugs, created via responsive prodrug-initiated controlled polymerization of lactide, demonstrated extremely high drug loading, tuneable stimuli-triggered drug release, and significant tumor growth inhibition and improved survival with minimal toxicity. This adaptable strategy can precisely tailor drugs’ physicochemical properties for optimal therapeutic efficacy, demonstrating great promise for cancer treatment.

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通过响应性前药引发的丙交酯开环聚合来改善药物传递的智能聚合物前药

智能聚合物前药是通过反应性前药引发的丙交酯控制聚合而产生的，具有极高的药物负荷、可调节的刺激触发的药物释放、显著的肿瘤生长抑制和低毒性的生存改善。这种适应性策略可以精确地调整药物的物理化学性质，以达到最佳的治疗效果，为癌症治疗展示了巨大的希望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nanoscale CHEMISTRY, MULTIDISCIPLINARY-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

12.10

自引率

3.00%

发文量

1628

审稿时长

1.6 months

期刊介绍： Nanoscale is a high-impact international journal, publishing high-quality research across nanoscience and nanotechnology. Nanoscale publishes a full mix of research articles on experimental and theoretical work, including reviews, communications, and full papers.Highly interdisciplinary, this journal appeals to scientists, researchers and professionals interested in nanoscience and nanotechnology, quantum materials and quantum technology, including the areas of physics, chemistry, biology, medicine, materials, energy/environment, information technology, detection science, healthcare and drug discovery, and electronics.