Precision Omics Initiative Sweden (PROMISE) will integrate research with healthcare

IF 58.7 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Medicine Pub Date : 2025-04-04 DOI:10.1038/s41591-025-03631-9

Anders Kämpe, Sanna Gudmundsson, Colum P. Walsh, Kerstin Lindblad-Toh, Åsa Johansson, Anna Clareborn, Adam Ameur, Anders Edsjö, Thoas Fioretos, Hans Ehrencrona, Daniel Eriksson, Tove Fall, Paul W. Franks, Ulf Gyllensten, Margareta Haag, Anna Hagwall, Maria Johansson Soller, Janne Lehtiö, Yi Lu, Patrik K. E. Magnusson, Erik Melén, Beatrice Melin, Karl Michaëlsson, Ann Nordgren, Jessica Nordlund, Lao H. Saal, Jochen M. Schwenk, Per Sikora, Johan Sundström, Fulya Taylan, Bethany Van Guelpen, Mia Wadelius, Anna Wedell, Valtteri Wirta, Päivi Östling, Bo Jacobsson, Tobias Sjöblom, Bengt Persson, Richard Rosenquist, Anna Lindstrand, Tuuli Lappalainen

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Abstract

Data-driven research and precision ‘-omics’ technologies have immense transformative potential to provide tailored treatment and care, embodying the principles of precision medicine. Sweden is a global leader in adopting genomic tools in healthcare. Still, national research datasets from human cohorts are too fragmented or too small to meet the needs of modern precision ‘-omics’ research. This positions Sweden behind its peer countries, with unmet research and healthcare implementation opportunities. However, the country is exceptionally well placed to change course, expand research data resources and adopt unique designs that integrate research and healthcare.

Here, we present Precision Omics Initiative Sweden (PROMISE)¹ and its three pillars: to generate extensive new large-scale multi-omics data with integration of selected existing research, registry and healthcare data; to maximize research use of ‘-omics’ data created in healthcare; and to develop an improved data-access framework.

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瑞典精密组学计划（PROMISE）将把研究与医疗保健结合起来

数据驱动的研究和精确“组学”技术在提供量身定制的治疗和护理方面具有巨大的变革潜力，体现了精确医学的原则。瑞典在医疗保健领域采用基因组工具方面处于全球领先地位。然而，来自人类群体的国家研究数据集过于分散或太小，无法满足现代精确“组学”研究的需要。这使得瑞典在研究和医疗保健实施机会方面落后于其他国家。然而，该国在改变路线、扩大研究数据资源和采用整合研究和医疗保健的独特设计方面处于非常有利的地位。在这里，我们提出了瑞典精确组学计划（PROMISE）1及其三大支柱：通过整合选定的现有研究、注册和医疗保健数据，生成广泛的新的大规模多组学数据；最大限度地利用医疗保健领域的“组学”数据进行研究；并开发一个改进的数据访问框架。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Medicine 医学-生化与分子生物学

CiteScore

100.90

自引率

0.70%

发文量

525

审稿时长

1 months

期刊介绍： Nature Medicine is a monthly journal publishing original peer-reviewed research in all areas of medicine. The publication focuses on originality, timeliness, interdisciplinary interest, and the impact on improving human health. In addition to research articles, Nature Medicine also publishes commissioned content such as News, Reviews, and Perspectives. This content aims to provide context for the latest advances in translational and clinical research, reaching a wide audience of M.D. and Ph.D. readers. All editorial decisions for the journal are made by a team of full-time professional editors. Nature Medicine consider all types of clinical research, including: -Case-reports and small case series -Clinical trials, whether phase 1, 2, 3 or 4 -Observational studies -Meta-analyses -Biomarker studies -Public and global health studies Nature Medicine is also committed to facilitating communication between translational and clinical researchers. As such, we consider “hybrid” studies with preclinical and translational findings reported alongside data from clinical studies.