Recent advances in research on Mycobacterium tuberculosis virulence factors and their role in pathogenesis.

Abstract

Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB) in humans and animals. Mtb invades the host's lungs via airborne transmission, infecting macrophages and causing TB. In some cases, the infection can spread to other tissues and organs. Despite the availability of several drugs for TB treatment, the emergence of multidrug-resistant TB has led to high morbidity and mortality rates worldwide. Therefore, it is urgent to discover new anti-tuberculosis drugs for more effective treatment. Recent studies have shown that Mtb virulence factors play a crucial role in its pathogenicity. By evading the host's immune surveillance through mechanisms such as anti-oxidative stress, nutrient synthesis and metabolism, and apoptosis in host cells, Mtb can achieve long-term survival in the host. Understanding the pathogenicity mechanisms of Mtb will aid the development of new vaccines and anti-tuberculosis drugs. In this review, we summarize the latest research progress on Mtb virulence factors to provide a reference for targeted TB treatment.