Comparison of the Humphrey Field Analyzer and MP-3 Microperimeter in Patients With Glaucoma, Classified by Severity and Misalignment of Test Points.

IF 2.6 3区医学 Q2 OPHTHALMOLOGY

Translational Vision Science & Technology Pub Date : 2025-04-01 DOI:10.1167/tvst.14.4.6

Taiga Inooka, Ryo Tomita, Taro Kominami, Marie Mochizuki, Koji M Nishiguchi, Kenya Yuki

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引用次数: 0

Abstract

Purpose: To compare Nidek MP-3 microperimetry and ZEISS Humphrey Field Analyzer (HFA) visual field (VF) results in patients with primary open-angle glaucoma (POAG), classified by VF defect severity and to describe a novel method for simulating sensitivity distribution changes assumed to be due to fixation errors.

Methods: This retrospective study used the MP-3 and HFA 10-2 tests to examine the VF in eyes with mild, moderate, or severe POAG, using 68 identical test points. Reliability indices and measurement durations were compared. The relationship between pointwise sensitivities of the devices was analyzed.

Results: Thirty-five eyes from 23 patients (10 mild, 12 moderate, and 13 severe POAG) were evaluated. In the severe POAG group, the MP-3 had a significantly lower false-positive (FP) rate and higher false-negative rate than those of the HFA 10-2 (all, P = 0.03). A significant negative correlation existed between the root mean square error, derived from regression analysis comparing the VF sensitivity between devices at each test point, and VF sensitivity of the MP-3 (P < 0.01). In 18 eyes, a shift in the sensitivity distribution occurred, with a significant correlation between the HFA 10-2 mean deviation and the presence of this shift (P < 0.01).

Conclusions: Reliability indices differed significantly between the two devices in severe POAG cases. A shift in the sensitivity of the test points of the two VF tests was detected in approximately one-half of the eyes.

Translational relevance: The MP-3 provides lower FP rates in advanced POAG and may assist in the management of this patient cohort.

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Humphrey Field分析仪和MP-3微周长在青光眼患者中的比较，按测试点的严重程度和偏差分类。

目的：比较Nidek MP-3显微镜和蔡司Humphrey Field Analyzer （HFA）视野（VF）对原发性开角型青光眼（POAG）患者的观察结果，并根据VF缺陷的严重程度进行分类，描述一种新的方法来模拟由固定误差引起的灵敏度分布变化。方法：本回顾性研究采用MP-3和HFA - 10-2试验，使用68个相同的测试点检查轻度、中度或重度POAG眼睛的VF。比较了可靠性指标和测量时间。分析了器件逐点灵敏度之间的关系。结果：对23例患者35只眼（轻度10只，中度12只，重度13只）进行评估。重度POAG组MP-3的假阳性（FP）率明显低于HFA 10-2，假阴性率明显高于HFA 10-2（均P = 0.03）。各测点设备间VF敏感性的回归分析得出的均方根误差与MP-3的VF敏感性呈显著负相关（P < 0.01）。18只眼的灵敏度分布发生移位，HFA 10-2平均偏差与这种移位存在显著相关性（P < 0.01）。结论：两种器械在重度POAG病例中的可靠性指标存在显著差异。在大约一半的眼睛中检测到两个VF测试的测试点的灵敏度的变化。翻译相关性：MP-3在晚期POAG中提供较低的FP率，可能有助于该患者队列的管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Translational Vision Science & Technology Engineering-Biomedical Engineering

CiteScore

5.70

自引率

3.30%

发文量

346

审稿时长

25 weeks

期刊介绍： Translational Vision Science & Technology (TVST), an official journal of the Association for Research in Vision and Ophthalmology (ARVO), an international organization whose purpose is to advance research worldwide into understanding the visual system and preventing, treating and curing its disorders, is an online, open access, peer-reviewed journal emphasizing multidisciplinary research that bridges the gap between basic research and clinical care. A highly qualified and diverse group of Associate Editors and Editorial Board Members is led by Editor-in-Chief Marco Zarbin, MD, PhD, FARVO. The journal covers a broad spectrum of work, including but not limited to: Applications of stem cell technology for regenerative medicine, Development of new animal models of human diseases, Tissue bioengineering, Chemical engineering to improve virus-based gene delivery, Nanotechnology for drug delivery, Design and synthesis of artificial extracellular matrices, Development of a true microsurgical operating environment, Refining data analysis algorithms to improve in vivo imaging technology, Results of Phase 1 clinical trials, Reverse translational ("bedside to bench") research. TVST seeks manuscripts from scientists and clinicians with diverse backgrounds ranging from basic chemistry to ophthalmic surgery that will advance or change the way we understand and/or treat vision-threatening diseases. TVST encourages the use of color, multimedia, hyperlinks, program code and other digital enhancements.