Clinical and epidemiological characteristics of the dengue outbreak of 2024: a multicenter observation from Bangladesh.

IF 3.6 Q1 TROPICAL MEDICINE

Tropical Medicine and Health Pub Date : 2025-04-02 DOI:10.1186/s41182-025-00691-y

Mohammad Jahid Hasan, Muna Islam, Tanjina Tabassum, Md Mohiuddin Khan, Md Khairul Islam, Rafiya Afroz, Rubaiya Rahman Tui, Mohammad Abdul Baset, Md Anwar Syed, Joarder Rakeen Manzoor, Mohiuddin Sharif, Tamanna Tabassum

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Abstract

Background: Dengue fever remains a significant public health challenge in Bangladesh. This study aimed to characterize the clinical and epidemiological profiles of confirmed dengue cases during the 2024 outbreak in Bangladesh.

Methods: This observational study was conducted from June to September 2024 in four tertiary care hospitals across Bangladesh located in four administrative divisions. A total of 401 laboratory-confirmed (NS1- or IgM-positive) dengue patients aged ≥ 12 years were included. Demographic data, clinical presentations, and laboratory findings were collected through face‒to-face interviews. The revised WHO 2009 dengue case classification was used for severity assessment of dengue patients. Descriptive and inferential statistics were used to summarize the results.

Results: The mean age of patients with dengue fever was 29.81 ± 11.64 (SD) years, with 7.2% of the patients being adolescents (aged 12-17 years). A clear male predominance (88.3%) was observed. Overall, 65.6% of patients had dengue with warning signs, and 9% had severe dengue. Fever (94.3%), headache (70.3%), myalgia (66.1%), and gastrointestinal symptoms such as nausea (49.9%) and abdominal pain (43.9%) were common symptoms. The median in-hospital stay of both non-severe and severe cases were 4 & 5 days, respectively. The in-hospital mortality rate was 0.75%, which was significantly higher among severe dengue patients (5.6%).

Conclusion: The 2024 dengue outbreak in Bangladesh predominantly affected young adult males, with a notable prevalence of gastrointestinal symptoms alongside classic dengue manifestations.

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2024年登革热暴发的临床和流行病学特征：来自孟加拉国的多中心观察

背景：登革热在孟加拉国仍然是一个重大的公共卫生挑战。本研究旨在描述2024年孟加拉国暴发期间登革热确诊病例的临床和流行病学概况。方法：这项观察性研究于2024年6月至9月在孟加拉国四个行政区的四家三级保健医院进行。共纳入401例年龄≥12岁的实验室确诊（NS1或igm阳性）登革热患者。通过面对面访谈收集人口统计数据、临床表现和实验室结果。修订的世卫组织2009年登革热病例分类用于评估登革热患者的严重程度。采用描述性统计和推理统计对结果进行总结。结果：登革热患者的平均年龄为29.81±11.64 （SD）岁，其中青少年（12-17岁）占7.2%。男性明显占优势（88.3%）。总体而言，65.6%的患者患有有警告信号的登革热，9%的患者患有严重登革热。常见症状为发热（94.3%）、头痛（70.3%）、肌痛（66.1%）、恶心（49.9%）、腹痛（43.9%）等胃肠道症状。非重症和重症病例的住院时间中位数分别为4天和5天。住院死亡率为0.75%，重症登革热患者的住院死亡率显著高于重症登革热患者（5.6%）。结论：孟加拉国2024年登革热疫情主要影响年轻成年男性，除典型登革热表现外，胃肠道症状显著流行。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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