Behavior of Soluble C-type Lectin-Like Receptor 2 levels in Patients with Coronavirus Disease 2019-associated with Thrombosis.

IF 5 2区医学 Q1 HEMATOLOGY

Thrombosis and haemostasis Pub Date : 2025-04-02 DOI:10.1055/a-2572-1170

Hideo Wada, Katsuya Shiraki, Yuhuko Ichkawa, Nobuo Ito, Hidekazu Inoue, Isao Moritani, Jun Masuda, Akitaka Yamamoto, Masaki Tomida, Masamichi Yoshida, Masahide Kawamura, Motomu Shimaoka, Toshi Iba, Hideto Shimpo

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引用次数: 0

Abstract

Background: Coronavirus disease 2019 (COVID-19) is often associated with thrombosis. Elevated levels of soluble C-type lectin-like receptor 2 (sCLEC-2), a biomarker for platelet activation, have been reported in COVID-19. Therefore, we examined the behavior of sCLEC-2 levels and their relationship with thrombosis.

Methods: The clinical course of inflammatory and thrombotic biomarkers was assessed in 271 patients with COVID-19.

Results: Inflammatory biomarkers such as C-reactive protein, procalcitonin and presepsin levels were significantly increased in patients with COVID-19, and these behaviors differed among the clinical course or stages. The plasma D-dimer levels increased slightly and gradually. Platelet counts were within the normal range, and plasma sCLEC-2 levels were markedly increased in most patients with COVID-19. There were 17 patients with thrombosis in this study. Although there was no significant difference in various biomarkers between COVID-19 patients with and without thrombosis, the super formula of sCLEC-2xD-dimer/platelet count in patients with thrombosis was significantly higher than in those without thrombosis. Furthermore, this super formula was significantly higher in COVID-19 patients with severe or critical illness than in those with mild or moderate illness.

Conclusion: Elevation of the super formula of sCLEC-2xD-dimer/platelet count was associated with the thrombosis in patients with COVID-19 suggesting the thrombosis in COVID-19 may be caused by the development of microthrombosis.

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可溶性c型凝集素样受体2在2019冠状病毒病与血栓形成相关患者中的行为

背景：冠状病毒病2019 （COVID-19）通常与血栓形成有关。可溶性c型凝集素样受体2 （scecc -2）水平升高，这是血小板活化的生物标志物，已在COVID-19中报道。因此，我们研究了scec2水平的行为及其与血栓形成的关系。方法：对271例新冠肺炎患者的炎症和血栓生物标志物的临床病程进行评估。结果：新冠肺炎患者c反应蛋白、降钙素原、血凝素等炎症生物标志物水平明显升高，且不同病程或分期患者的这些行为存在差异。血浆d -二聚体水平逐渐轻微升高。大多数患者血小板计数在正常范围内，血浆sclc -2水平明显升高。本研究共有17例患者出现血栓形成。尽管有和无血栓形成的COVID-19患者各项生物标志物无显著差异，但血栓形成患者scecc - 2xd -二聚体/血小板计数的超配方明显高于无血栓形成的患者。重症、危重症患者的超配方含量明显高于轻、中度疾病患者。结论：scecc - 2xd -二聚体/血小板计数超方升高与新冠肺炎患者血栓形成相关，提示新冠肺炎患者血栓形成可能是由微血栓形成所致。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Thrombosis and haemostasis 医学-外周血管病

CiteScore

11.90

自引率

9.00%

发文量

140

审稿时长

1 months

期刊介绍： Thrombosis and Haemostasis publishes reports on basic, translational and clinical research dedicated to novel results and highest quality in any area of thrombosis and haemostasis, vascular biology and medicine, inflammation and infection, platelet and leukocyte biology, from genetic, molecular & cellular studies, diagnostic, therapeutic & preventative studies to high-level translational and clinical research. The journal provides position and guideline papers, state-of-the-art papers, expert analysis and commentaries, and dedicated theme issues covering recent developments and key topics in the field.