Prognostic significance of the liver stiffness value on magnetic resonance imaging elastography in patients undergoing hepatectomy for hepatocellular carcinoma.

IF 1.7 4区医学 Q2 SURGERY

Surgery Today Pub Date : 2025-04-03 DOI:10.1007/s00595-025-03034-w

Hiroto Chiba, Naoya Sato, Atsushi Ozeki, Ryota Sugawara, Takayasu Azuma, Shigeyuki Tsukida, Makoto Muto, Junichiro Haga, Yasuhide Kofunato, Teruhide Ishigame, Takashi Kimura, Akira Kenjo, Shigeru Marubashi

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引用次数: 0

Abstract

Synopsis: This study shows the utility of magnetic resonance imaging elastography as an independent predictor of the postoperative recurrence of hepatocellular carcinoma.

Purpose: Accurate assessment of postoperative recurrence risk is crucial for the perioperative management of patients undergoing surgical resection for hepatocellular carcinoma (HCC). Magnetic resonance imaging elastography (MRE) has emerged as a noninvasive tool for assessing liver fibrosis. This study evaluated whether MRE independently predicts HCC recurrence more effectively than well-known oncological factors, including pathological findings.

Methods: The subjects of this retrospective observational study were HCC patients who underwent preoperative MRE and hepatectomy between 2013 and 2023. Data collected included demographics, laboratory findings, imaging, pathology, operative details, and prognosis. Patients were followed up for at least 1 year after hepatectomy or until recurrence.

Results: Recurrence developed in 46 of 100 patients. Multivariable Cox regression analysis for overall recurrence identified MRE ≥ 3.7 kPa (hazard ratio [HR] 3.161, p = 0.021), the FIB-4 index (HR 3.176, p = 0.001), tumor size > 5 cm (HR 5.893, p < 0.001), invasive growth pattern (HR 2.375, p = 0.036), METAVIR F3-4 (HR 2.562, p = 0.046), and venous invasion (HR 10.622, p < 0.001) as risk factors. The recurrence-free rate at 1 year for patients with MRE ≥ 3.7 kPa was lower than for those with MRE < 3.7 kPa (72.0% vs. 92.0%, p = 0.017).

Conclusions: Preoperative MRE predicts postoperative HCC recurrence, underscoring its utility in risk stratification.

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肝细胞癌肝切除术患者磁共振成像弹性成像肝刚度值的预后意义。

摘要：本研究显示磁共振成像弹性成像作为肝细胞癌术后复发的独立预测指标的效用。目的：准确评估术后复发风险对肝细胞癌（HCC）手术切除患者围手术期管理至关重要。磁共振成像弹性成像（MRE）已成为一种评估肝纤维化的无创工具。本研究评估了MRE是否比众所周知的肿瘤因素（包括病理结果）更有效地独立预测HCC复发。方法：这项回顾性观察性研究的对象是2013年至2023年间接受术前MRE和肝切除术的HCC患者。收集的资料包括人口统计学、实验室结果、影像学、病理、手术细节和预后。患者在肝切除术后随访至少1年或直至复发。结果：100例患者中有46例复发。多变量Cox回归分析确定MRE≥3.7 kPa（风险比[HR] 3.161, p = 0.021）， FIB-4指数（HR 3.176, p = 0.001），肿瘤大小bbb50 cm （HR 5.893, p）。结论：术前MRE预测术后HCC复发，强调其在风险分层中的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Surgery Today 医学-外科

CiteScore

4.90

自引率

4.00%

发文量

208

审稿时长

1 months

期刊介绍： Surgery Today is the official journal of the Japan Surgical Society. The main purpose of the journal is to provide a place for the publication of high-quality papers documenting recent advances and new developments in all fields of surgery, both clinical and experimental. The journal welcomes original papers, review articles, and short communications, as well as short technical reports("How to do it"). The "How to do it" section will includes short articles on methods or techniques recommended for practical surgery. Papers submitted to the journal are reviewed by an international editorial board. Field of interest: All fields of surgery.