Nikolaos S Georgopoulos, Maria Tolia, Annita Boulouta, Anastasios Kyriazoglou, Vasileios Patriarcheas, Evangelos Dimakakos, Dimitrios Schizas, Davide Mauri, Nikolaos Tsoukalas, Nikolaos Chalampakis, Ramon Andrade De Mello, Chrysostomos Antoniadis, Eelco de Bree, Dimosthenis Michelakis, Konstantinos Tsapakidis, Michalis Mazonakis, Pantelis Kountourakis, Ioanna Nixon, Dimitrios Mavroudis, Areti Gkantaifi
{"title":"Wound Healing Complications after Neoadjuvant Radiotherapy Combined with Targeted Therapies in Soft Tissue Sarcoma Patients.","authors":"Nikolaos S Georgopoulos, Maria Tolia, Annita Boulouta, Anastasios Kyriazoglou, Vasileios Patriarcheas, Evangelos Dimakakos, Dimitrios Schizas, Davide Mauri, Nikolaos Tsoukalas, Nikolaos Chalampakis, Ramon Andrade De Mello, Chrysostomos Antoniadis, Eelco de Bree, Dimosthenis Michelakis, Konstantinos Tsapakidis, Michalis Mazonakis, Pantelis Kountourakis, Ioanna Nixon, Dimitrios Mavroudis, Areti Gkantaifi","doi":"10.2174/0115748871354960250315170817","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction/objective: </strong>Significant advancements have been achieved with the use of targeted molecular therapies for the treatment of Soft Tissue Sarcomas (STS). However, data remains scarce about the potential benefits and toxicity of this therapeutic option. In this narrative review, we aim to better clarify the potential wound healing complications in STS patients undergoing neoadjuvant (NA) radiotherapy (RT), combined with targeted therapies.</p><p><strong>Methods: </strong>We used the PubMed database to retrieve journal articles and the inclusion criteria were all studies that illustrated the potential RT toxicity, combined with targeted therapies, in the NA setting of STS patients.</p><p><strong>Results: </strong>Our search resulted in seven studies that fulfilled the inclusion criteria. Delayed wound complication rates were observed similarly to RT alone, while one study reported intolerable toxicity without referring specifically to wound complications.</p><p><strong>Conclusion: </strong>The combination of RT with targeted therapies in STS seems to be effective and well tolerated. Due to the lack of studies with high level of evidence, further research is required to enhance the existing knowledge for its potential value in this field.</p>","PeriodicalId":21174,"journal":{"name":"Reviews on recent clinical trials","volume":" ","pages":""},"PeriodicalIF":1.4000,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Reviews on recent clinical trials","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/0115748871354960250315170817","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction/objective: Significant advancements have been achieved with the use of targeted molecular therapies for the treatment of Soft Tissue Sarcomas (STS). However, data remains scarce about the potential benefits and toxicity of this therapeutic option. In this narrative review, we aim to better clarify the potential wound healing complications in STS patients undergoing neoadjuvant (NA) radiotherapy (RT), combined with targeted therapies.
Methods: We used the PubMed database to retrieve journal articles and the inclusion criteria were all studies that illustrated the potential RT toxicity, combined with targeted therapies, in the NA setting of STS patients.
Results: Our search resulted in seven studies that fulfilled the inclusion criteria. Delayed wound complication rates were observed similarly to RT alone, while one study reported intolerable toxicity without referring specifically to wound complications.
Conclusion: The combination of RT with targeted therapies in STS seems to be effective and well tolerated. Due to the lack of studies with high level of evidence, further research is required to enhance the existing knowledge for its potential value in this field.
期刊介绍：
Reviews on Recent Clinical Trials publishes frontier reviews on recent clinical trials of major importance. The journal"s aim is to publish the highest quality review articles in the field. Topics covered include: important Phase I – IV clinical trial studies, clinical investigations at all stages of development and therapeutics. The journal is essential reading for all researchers and clinicians involved in drug therapy and clinical trials.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
