Utility of Diffusion Tensor Imaging in Predicting Outcomes Following Surgical Treatment of Degenerative Cervical Myelopathy.

IF 0.9 3区医学 Q4 NEUROSCIENCES

Neurology India Pub Date : 2025-03-01 Epub Date: 2025-04-03 DOI:10.4103/neurol-india.Neurol-India-D-24-00271

Selvin Prabhakar, Pratyush Shahi, Md Tosaddeque Hussain, Mona Tiwari, Christopher Gerber, Anindya Basu

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Abstract

Background: The utility of diffusion tensor imaging (DTI) in predicting surgical outcomes in degenerative cervical myelopathy (DTI) remains controversial.

Objective: To identify the preoperative clinical and radiological factors associated with poor outcomes following surgical treatment of DCM.

Methods and material: This prospective cohort study included patients who underwent surgery for DCM. MRI parameters (compression ratio, CR; transverse area, TA; signal-intensity ratio, SIR) and DTI parameters (fractional anisotropy, FA; apparent diffusion coefficient, ADC; relative anisotropy, RA; volume ratio, VR) were assessed preoperatively. Demographic and operative data were collected. Based on the improvement in modified Japanese Orthopaedic Association (mJOA) score at 4 months, patients were categorized as group A (good surgical outcome) and group B (poor surgical outcome). Univariate and regression analyses were performed to identify risk factors and predictors, respectively, of poor surgical outcome.

Results: Sixty-six patients were included. Thirty-eight patients belonged to group A (good outcome) and 28 patients belonged to group B (poor outcome). There was no significant difference between the two groups in demographic and operative variables. FA was found to be significantly less in group B compared to group A (550 vs. 610, P = 0.04). No significant difference was seen in RA, CR, TA, SIR, ADC, and VR between the two groups. On regression analysis, no independent predictor of poor outcome could be identified.

Conclusions: Preoperative FA was found to be significantly lower in patients with poor outcome following surgical treatment for DCM.

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来源期刊

Neurology India 医学-神经科学

CiteScore

1.60

自引率

70.40%

发文量

434

审稿时长

2 months

期刊介绍： Neurology India (ISSN 0028-3886) is Bi-monthly publication of Neurological Society of India. Neurology India, the show window of the progress of Neurological Sciences in India, has successfully completed 50 years of publication in the year 2002. ‘Neurology India’, along with the Neurological Society of India, has grown stronger with the passing of every year. The full articles of the journal are now available on internet with more than 20000 visitors in a month and the journal is indexed in MEDLINE and Index Medicus, Current Contents, Neuroscience Citation Index and EMBASE in addition to 10 other indexing avenues. This specialty journal reaches to about 2000 neurologists, neurosurgeons, neuro-psychiatrists, and others working in the fields of neurology.