Simultaneous Nonmotor Symptoms Do Not Affect General Validity but Interpretation of the Parkinson's Disease Motor Diary.

IF 2.6 4区医学 Q2 CLINICAL NEUROLOGY

Movement Disorders Clinical Practice Pub Date : 2025-04-03 DOI:10.1002/mdc3.70061

Hampus Andersson, Alexander Bremer, Florin Gandor, Georg Ebersbach, Matthias Löhle, Per Odin, Alexander Storch

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Abstract

Background: Motor fluctuations are routinely documented using the Parkinson's disease (PD) home diary. However, the validity of this diary when compared to clinical observers is limited.

Objective: This study disassembled the effects of nonmotor symptoms (NMS) on inter-method agreement between the PD home motor diary and clinical observers (outside validity criterion).

Methods: A prospective observational VALIDATE-PD cohort study in advanced PD assessing symptom severity by simultaneous hourly ratings using the home diary (Off, On, dyskinetic state) and a nonmotor diary (11 key NMSs) was performed. Test validity measures (accuracy and Cohen's κ) were compared between hours with and without co-occurring NMS.

Results: Four hundred eighty-seven hourly time periods from 47 participants were analyzed. Inter-method agreement (accuracy, Cohen's κ) of the motor diary was independent of co-occurring NMSs, but simultaneous NMSs inversely influence false ratings of motor Off and On states.

Conclusions: Simultaneously occurring NMSs do not affect general validity but the interpretation of the PD home motor diary.

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同时出现的非运动症状不会影响帕金森病运动日记的一般有效性，但会影响其解释。

背景：运动波动是帕金森病（PD）家庭日记的常规记录。然而，与临床观察相比，该日记的有效性是有限的。目的：探讨非运动症状（NMS）对PD家庭运动日记与临床观察者（外部效度标准）方法间一致性的影响。方法：对晚期PD患者进行前瞻性观察性VALIDATE-PD队列研究，通过使用家庭日记（关闭、打开、运动障碍状态）和非运动日记（11个关键NMSs）同时进行每小时评分来评估症状严重程度。在有和没有同时发生NMS的小时之间比较测试效度测量（准确性和Cohen's κ）。结果：对47名参与者的487个小时时段进行了分析。运动日志的方法间一致性（准确性，Cohen’s κ）与共同发生的NMSs无关，但同时发生的NMSs对运动Off和On状态的错误评级呈负相关。结论：同时发生的NMSs不影响一般效度，但影响PD家庭运动日记的解释。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Movement Disorders Clinical Practice CLINICAL NEUROLOGY-

CiteScore

4.00

自引率

7.50%

发文量

218

期刊介绍： Movement Disorders Clinical Practice- is an online-only journal committed to publishing high quality peer reviewed articles related to clinical aspects of movement disorders which broadly include phenomenology (interesting case/case series/rarities), investigative (for e.g- genetics, imaging), translational (phenotype-genotype or other) and treatment aspects (clinical guidelines, diagnostic and treatment algorithms)