Preparation and evaluation of topical span 60-based oleogel of voriconazole.

IF 1.4 Q3 Pharmacology, Toxicology and Pharmaceutics
Hiba Muneer Fysal, Hanan Jalal Kassab
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引用次数: 0

Abstract

Voriconazole (VOR) is a triazole antifungal agent; it blocks the synthesis of ergosterol, available in the market orally and intravenously, but, not without various side effects. The aim of this study is development and characterization of VOR oleogel for the topical treatment of skin fungal infection to avoid the drug's systemic side effects that are associated with oral and IV routes. The gelator Span 60 (S) was added at different concentrations to different oils (oleic OO, grapeseed GO, and sesame oil SO) to obtain the minimum gelation concentration, the prepared formulas were subjected to various evaluation tests, and the optimum formula was checked for antifungal effect, and subjected to viscosity, and texture analysis. The optimized formula, Span60 with SO 14SSO, showed 100% drug release, good antifungal activity, and acceptable transition temperature. The study of viscosity demonstrated the pseudo-plastic shear thinning behavior. A Fourier-transform infrared study showed that the drug and excipients did not significantly interact. 14SSO might be a promising topical treatment option for skin fungal infections.

以 span 60 为基础的伏立康唑局部用油凝胶的制备和评估。
伏立康唑(Voriconazole, VOR)是一种三唑类抗真菌药物;它阻断麦角甾醇的合成,市面上有口服和静脉注射的麦角甾醇,但是,并非没有各种副作用。本研究的目的是开发和表征用于局部治疗皮肤真菌感染的VOR油凝胶,以避免药物与口服和静脉注射途径相关的全身副作用。将胶凝剂Span 60 (S)以不同的浓度加入到不同的油脂(油酸OO、葡萄籽GO和芝麻油SO)中,以获得最小的胶凝浓度,并对所制备的配方进行了各种评价试验,对最佳配方进行了抗真菌效果检查,并进行了粘度和质地分析。优化后的配方为含so14sso的Span60,释药100%,抗真菌活性良好,转化温度适宜。对黏度的研究证实了其伪塑性剪切减薄行为。傅里叶变换红外研究表明,药物和辅料之间没有明显的相互作用。sso可能是一种很有前途的局部治疗皮肤真菌感染的选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.00
自引率
7.10%
发文量
44
审稿时长
20 weeks
期刊介绍: Journal of Advanced Pharmaceutical Technology & Research (JAPTR) is an Official Publication of Society of Pharmaceutical Education & Research™. It is an international journal published Quarterly. Journal of Advanced Pharmaceutical Technology & Research (JAPTR) is available in online and print version. It is a peer reviewed journal aiming to communicate high quality original research work, reviews, short communications, case report, Ethics Forum, Education Forum and Letter to editor that contribute significantly to further the scientific knowledge related to the field of Pharmacy i.e. Pharmaceutics, Pharmacology, Pharmacognosy, Pharmaceutical Chemistry. Articles with timely interest and newer research concepts will be given more preference.
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