Distribution of lipoprotein (a) levels in patients with lower extremity artery disease and their impact on amputation and survival: a retrospective study.

IF 3.9 2区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Lipids in Health and Disease Pub Date : 2025-04-02 DOI:10.1186/s12944-025-02542-5

Katrin Gebauer, Nasser M Malyar, Julian Varghese, Holger Reinecke, Tobias J Brix, Christiane Engelbertz

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引用次数: 0

Abstract

Background: Elevated lipoprotein (a) (Lp(a)) is an independent risk factor for lower extremity artery disease (LEAD) with equivocal effect on amputation and mortality. Results regarding aggressive lipid-lowering therapies (LLT) are missing. We examined LEAD patients with Lp(a) measurement and the impact of intensive LLT on amputation and survival.

Methods: Baseline characteristics of 263 LEAD patients with Lp(a) measurement treated in a tertiary hospital from 01/2017 until 01/2022 were recorded. Patients were categorized into three groups according to their Lp(a) values (< 30 mg/dL, 30-90 mg/dL and > 90 mg/dL). Lipid values and LLT were recorded at baseline and during follow-up (median 750 days). Peripheral endovascular revascularizations (EVR), amputations and death during follow-up were analysed.

Results: Of 263 patients, 75% were male, mean age was 67 ± 10 years. Elevated Lp(a) values ≥ 30 mg/dL were found in 32%, 16% had values > 90 mg/dL. Baseline low-density lipoprotein cholesterol (LDL-C) was 89 ± 38 mg/dL, decreasing to 61 ± 30 mg/dL at follow-up, with no difference between Lp(a) groups (63 ± 32 mg/dL vs. 52 ± 23 mg/dL vs. 60 ± 25 mg/dL, p = 0.273). Statin dose was intensified more frequently in those with elevated Lp(a) (16% vs. 35% vs. 33%, p = 0.005), who also received significantly more often ezetimibe (50% vs. 58% vs. 73%, p = 0.028) and proprotein convertase subtilisin/kexin type 9 inhibitors (2% vs. 3% vs. 8%, p = 0.043). No difference was seen regarding EVR (91% vs. 95% vs. 90%, p = 0.729), amputations (4% vs. 7% vs. 0%, p = 0.245) and death (8% vs. 5% vs. 3%, p = 0.436).

Conclusions: Aggressive LLT in high-risk LEAD patients with elevated Lp(a) levels enabled LDL-C target achievement in a majority by combination of established lipid-lowering agents. An increase in EVR, amputation or death could not be observed in patients with high Lp(a) levels.

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下肢动脉疾病患者的脂蛋白(a)水平分布及其对截肢和生存的影响：一项回顾性研究

背景：脂蛋白(a)升高（Lp(a)）是下肢动脉疾病（LEAD）的独立危险因素，对截肢和死亡率的影响模棱两可。关于积极降脂疗法（LLT）的结果尚不清楚。我们检查了Lp(a)测量的LEAD患者以及强化LLT对截肢和生存的影响。方法：记录2017年1月至2022年1月在某三级医院接受Lp(a)测量的263例铅患者的基线特征。根据Lp(a)值（90 mg/dL）将患者分为三组。在基线和随访期间（中位750天）记录脂质值和LLT。分析随访期间外周血管内重建（EVR）、截肢和死亡情况。结果：263例患者中男性占75%，平均年龄67±10岁。32%的患者Lp(a)升高≥30mg /dL， 16%的患者Lp(a)升高至bb0 ~ 90mg /dL。基线低密度脂蛋白胆固醇（LDL-C）为89±38 mg/dL，随访时降至61±30 mg/dL， Lp(a)组之间无差异（63±32 mg/dL vs 52±23 mg/dL vs 60±25 mg/dL, p = 0.273）。在Lp(a)升高的患者中，他汀类药物的剂量更频繁地增加（16%对35%对33%，p = 0.005），他们也更频繁地接受依折替米比（50%对58%对73%，p = 0.028）和蛋白转化酶枯草杆菌素/ keexin 9型抑制剂（2%对3%对8%，p = 0.043）。EVR （91% vs. 95% vs. 90%, p = 0.729）、截肢（4% vs. 7% vs. 0%, p = 0.245）和死亡（8% vs. 5% vs. 3%, p = 0.436）无差异。结论：在Lp(a)水平升高的高危LEAD患者中，侵袭性LLT通过联合使用已建立的降脂药物，大多数能够实现LDL-C目标。在高Lp(a)水平的患者中未观察到EVR、截肢或死亡的增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lipids in Health and Disease 生物-生化与分子生物学

CiteScore

7.70

自引率

2.20%

发文量

122

审稿时长

3-8 weeks

期刊介绍： Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.