Xuemei Quan, Lei Zhao, Jingyu Jin, Changzhe Jing, Kun Yang, Shan Jin, Zhehu Jin
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引用次数: 0
Abstract
The pathogenesis of keloid is complex and unclear, and current therapies of this condition remain unsatisfactory. Dehydroepiandrosterone (DHEA), a steroid prohormone, exhibits a wide range of pharmacologic activities, including anti-inflammatory and pro-immune effects, as well as anti-tumor and anti-fibrotic properties. Herein, the authors explored the potential effects and underlying mechanisms of DHEA on keloid fibroblasts in vitro. The authors' findings indicated that DHEA significantly inhibited the proliferation, migration, and invasion of keloid fibroblasts, while promoting cell apoptosis. In addition, DHEA significantly reduced the expression of fibrosis-related proteins in keloid fibroblasts by suppressing the TGF-β1/Smad signaling pathway. In conclusion, the authors' in vitro results highlight the therapeutic potential of DHEA as a promising candidate for keloid treatment.
期刊介绍:
The Journal of Craniofacial Surgery serves as a forum of communication for all those involved in craniofacial surgery, maxillofacial surgery and pediatric plastic surgery. Coverage ranges from practical aspects of craniofacial surgery to the basic science that underlies surgical practice. The journal publishes original articles, scientific reviews, editorials and invited commentary, abstracts and selected articles from international journals, and occasional international bibliographies in craniofacial surgery.