Dehydroepiandrosterone Suppresses Keloid Fibroblasts Fibrosis by Inhibiting the TGF-β1/Smad Signaling Pathway.

IF 1 4区 医学 Q3 SURGERY
Xuemei Quan, Lei Zhao, Jingyu Jin, Changzhe Jing, Kun Yang, Shan Jin, Zhehu Jin
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引用次数: 0

Abstract

The pathogenesis of keloid is complex and unclear, and current therapies of this condition remain unsatisfactory. Dehydroepiandrosterone (DHEA), a steroid prohormone, exhibits a wide range of pharmacologic activities, including anti-inflammatory and pro-immune effects, as well as anti-tumor and anti-fibrotic properties. Herein, the authors explored the potential effects and underlying mechanisms of DHEA on keloid fibroblasts in vitro. The authors' findings indicated that DHEA significantly inhibited the proliferation, migration, and invasion of keloid fibroblasts, while promoting cell apoptosis. In addition, DHEA significantly reduced the expression of fibrosis-related proteins in keloid fibroblasts by suppressing the TGF-β1/Smad signaling pathway. In conclusion, the authors' in vitro results highlight the therapeutic potential of DHEA as a promising candidate for keloid treatment.

脱氢表雄酮通过抑制 TGF-β1/Smad 信号通路抑制瘢痕成纤维细胞纤维化
瘢痕疙瘩的发病机制复杂而不清楚,目前的治疗方法仍不令人满意。脱氢表雄酮(DHEA)是一种类固醇原激素,具有广泛的药理活性,包括抗炎和促免疫作用,以及抗肿瘤和抗纤维化特性。在此,作者探讨了脱氢表雄酮对瘢痕疙瘩成纤维细胞的潜在作用及其机制。结果表明,脱氢表雄酮显著抑制瘢痕疙瘩成纤维细胞的增殖、迁移和侵袭,同时促进细胞凋亡。此外,DHEA通过抑制TGF-β1/Smad信号通路,显著降低瘢痕疙瘩成纤维细胞中纤维化相关蛋白的表达。总之,作者的体外实验结果突出了脱氢表雄酮作为瘢痕疙瘩治疗的有希望的候选药物的治疗潜力。
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来源期刊
CiteScore
1.70
自引率
11.10%
发文量
968
审稿时长
1.5 months
期刊介绍: ​The Journal of Craniofacial Surgery serves as a forum of communication for all those involved in craniofacial surgery, maxillofacial surgery and pediatric plastic surgery. Coverage ranges from practical aspects of craniofacial surgery to the basic science that underlies surgical practice. The journal publishes original articles, scientific reviews, editorials and invited commentary, abstracts and selected articles from international journals, and occasional international bibliographies in craniofacial surgery.
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