Vasodilator activity of methanol extract obtained from Crataegus rosei leaves and the chemical characterization of its main constituents.

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-04-03 DOI:10.1080/14786419.2025.2486334

Diana López-Fitz, Eloy Rodríguez-de-León, Rebeca Rodríguez-Martínez, César Ibarra-Alvarado, Moustapha Bah, Mahinda Martínez, Leticia García-Aguilar

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Abstract

Persistent arterial hypertension (AHT) plays a very important role in the development of cardiovascular diseases (CVD). The present study assessed the vasodilator activities of the methanol extract (ME) and its fractions obtained from leaves of a Mexican Crataegus rosei plant. The fat- and tannin-free ME fraction (FTFME) produced the most potent vasodilator effect [EC₅₀ 8.253 (4.672 to 14.58 μg/mL)], that was 6.7-fold higher than that of the ME [EC₅₀ = 55.49 (29.78 to 68.69) μg/mL], which was similar to that of ACh used as a positive control. This effect was dependent on the nitric oxide/cGMP pathway. Six triterpene acids (ursolic, oleanolic, euscaphic, maslinic, corosolic, and alphitolic) were identified as the main constituents of this fraction. In contrast to the commercially available Crataegus extracts, these compounds must be the most suitable chemical and pharmacological markers for this methanol extract in research into obtaining a standardised antihypertensive extract.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.