The development of a person-centred self-report instrument to investigate quality-of-life aspects of gallstone surgery - The Gothenburg gallstone questionnaires (GGQ24pre & GGQ21post).

IF 2.7 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Hpb Pub Date : 2025-03-08 DOI:10.1016/j.hpb.2025.02.015

Simon H Pålsson, Cecilia Engström, Jenny Skoog, Stefan Redéen, Lars Enochsson, Lise-Lott Prebner, Johanna Österberg, Fredrik Linder, Eva-Lena Syrén, Gabriel Sandblom, John Eric Chaplin

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Abstract

Background: To develop and psychometrically test a condition-specific, patient-reported outcomes instrument for patients undergoing gallstone surgery.

Methods: A mixed-methods design, including six gender-mixed patient focus-groups was used. Statements were thematically analysed and compared to PROMIS and the Gastrointestinal Quality of Life Index (GIQLI). A pilot questionnaire of 63 items and the full scale GIQLI was sent to preoperative and 30 items were sent to postoperative patients. Factor analysis identified structure and redundant items. Short versions were assessed to ensure internal reliability and validity. Unidimensionality was assessed via graded response model.

Results: 273 patients completed the questionnaires (preoperatively n = 104 and postoperatively n = 169). Factor and IRT analysis identified 13 domains with 45 questions. Internal reliability 0.75 to 0.93 in the preoperative and 0.73 to 0.90 in the postoperative questionnaire. A PROM questionnaire was developed with pre- and postoperative modules (24 questions, 8 domains and 21 questions, 5 domains).

Conclusion: This study has shown the validity of a disease specific Health Related Quality-of-Life (HRQoL) instrument in a population with gallstone disease and a post-operative module for follow-up. Further testing in a longitudinal cohort is recommended in order to establish responsiveness.

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来源期刊

Hpb GASTROENTEROLOGY & HEPATOLOGY-SURGERY

CiteScore

5.60

自引率

3.40%

发文量

244

审稿时长

57 days

期刊介绍： HPB is an international forum for clinical, scientific and educational communication. Twelve issues a year bring the reader leading articles, expert reviews, original articles, images, editorials, and reader correspondence encompassing all aspects of benign and malignant hepatobiliary disease and its management. HPB features relevant aspects of clinical and translational research and practice. Specific areas of interest include HPB diseases encountered globally by clinical practitioners in this specialist field of gastrointestinal surgery. The journal addresses the challenges faced in the management of cancer involving the liver, biliary system and pancreas. While surgical oncology represents a large part of HPB practice, submission of manuscripts relating to liver and pancreas transplantation, the treatment of benign conditions such as acute and chronic pancreatitis, and those relating to hepatobiliary infection and inflammation are also welcomed. There will be a focus on developing a multidisciplinary approach to diagnosis and treatment with endoscopic and laparoscopic approaches, radiological interventions and surgical techniques being strongly represented. HPB welcomes submission of manuscripts in all these areas and in scientific focused research that has clear clinical relevance to HPB surgical practice. HPB aims to help its readers - surgeons, physicians, radiologists and basic scientists - to develop their knowledge and practice. HPB will be of interest to specialists involved in the management of hepatobiliary and pancreatic disease however will also inform those working in related fields. Abstracted and Indexed in: MEDLINE® EMBASE PubMed Science Citation Index Expanded Academic Search (EBSCO) HPB is owned by the International Hepato-Pancreato-Biliary Association (IHPBA) and is also the official Journal of the American Hepato-Pancreato-Biliary Association (AHPBA), the Asian-Pacific Hepato Pancreatic Biliary Association (A-PHPBA) and the European-African Hepato-Pancreatic Biliary Association (E-AHPBA).