Impact of Resting Heart Rate and Predicted Cardiovascular Risk on Mortality in nearly 110,000 Chinese Adults.

IF 5.6 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Heart rhythm Pub Date : 2025-03-31 DOI:10.1016/j.hrthm.2025.03.1990

Anna Shen, Fangchao Liu, Shufeng Chen, Keyong Huang, Jie Cao, Chong Shen, Xiaoqing Liu, Ling Yu, Shujun Gu, Liancheng Zhao, Ying Li, Dongsheng Hu, Jianfeng Huang, Xiangfeng Lu, Dongfeng Gu, Jianxin Li

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引用次数: 0

Abstract

Background: The association of mortality with resting heart rate (RHR) and predicted risk of incident cardiovascular disease (CVD) has not been comprehensively elucidated.

Objective: To evaluate the individual and combined impacts of RHR and predicted CVD risk on mortality among Chinese adults.

Methods: A total of 108,257 Chinese adults were followed up during 1992 to 2015. The Cox proportional hazards model was employed to assess the hazard ratio (HR) and 95% confidence interval (CI) of mortality associated with RHR and the predicted risk of incident CVD.

Results: During an average of 8.53 years of follow-up, we identified 6267 non-accidental deaths, including 2324 CVD deaths. High-RHR participants had higher HRs of non-accidental (1.58; 95%CI: 1.47, 1.70), CVD (1.71; 95%CI: 1.53, 1.92), and non-CVD mortality (1.50; 95%CI: 1.37, 1.64) than low-RHR ones, respectively. Compare to individuals with low CVD risk, those with high CVD risk demonstrated HRs of 1.67 (95%CI: 1.51, 1.83) and 3.90 (95%CI: 3.29, 4.61) for non-accidental and CVD mortality, respectively. The mortality risk gradually increased with the elevation of CVD risk and RHR, showing the greatest HRs of non-accidental (2.57; 95%CI: 2.24, 2.94) and CVD mortality (7.16; 95%CI: 5.52, 9.29) among participants with both high CVD risk and high RHR.

Conclusion: Our findings demonstrated that RHR and CVD risk are independently associated with mortality, and integrating them could potentially refine risk stratification of mortality. It highlighted the important role of them in personalized strategies for primordial and primary prevention.

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来源期刊

Heart rhythm 医学-心血管系统

CiteScore

10.50

自引率

5.50%

发文量

1465

审稿时长

24 days

期刊介绍： HeartRhythm, the official Journal of the Heart Rhythm Society and the Cardiac Electrophysiology Society, is a unique journal for fundamental discovery and clinical applicability. HeartRhythm integrates the entire cardiac electrophysiology (EP) community from basic and clinical academic researchers, private practitioners, engineers, allied professionals, industry, and trainees, all of whom are vital and interdependent members of our EP community. The Heart Rhythm Society is the international leader in science, education, and advocacy for cardiac arrhythmia professionals and patients, and the primary information resource on heart rhythm disorders. Its mission is to improve the care of patients by promoting research, education, and optimal health care policies and standards.