Meta-analysis of altered gray matter volume in acute lymphoblastic leukemia patients' postchemotherapy via the AES-SDM.

IF 2.8 3区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

European Journal of Medical Research Pub Date : 2025-04-02 DOI:10.1186/s40001-025-02461-2

Xuelian Zong, Huiping Liu, Xiaoyun Zhao

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引用次数: 0

Abstract

Background: Voxel-based morphometry (VBM) reveals diverse alterations in gray matter volume in acute lymphoblastic leukemia (ALL) patients after chemotherapy. However, the reported results are inconsistent. Therefore, our objective was to conduct a meta-analysis to synthesize findings from existing VBM studies and identify consistent patterns of altered gray matter volume in ALL patients post-chemotherapy.

Materials and methods: A systematic search was conducted across PubMed, Web of Knowledge, Embase, Google Scholar, and CNKI for VBM studies that compared ALL patients post-chemotherapy with healthy controls (HCs) up to April 1, 2024. Significant cluster coordinates were extracted for comprehensive analysis.

Results: We included 7 studies involving 143 ALL patients post-chemotherapy and 140 HCs. ALL patients who underwent chemotherapy presented decreased gray matter volume in the left caudate nucleus, left calcarine fissure/surrounding cortex, left precentral gyrus and right anterior thalamic projections. Jackknife sensitivity analysis validated the robustness of these findings.

Conclusions: This meta-analysis revealed consistent gray matter volume alterations in ALL patients post-chemotherapy, emphasizing the need to explore their underlying mechanisms and long-term effects on cognitive and neurological health.

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急性淋巴细胞白血病患者化疗后灰质体积改变的meta分析

背景：基于体素的形态测定（VBM）揭示了急性淋巴细胞白血病（ALL）患者化疗后灰质体积的不同变化。然而，报道的结果并不一致。因此，我们的目标是进行一项荟萃分析，综合现有VBM研究的结果，并确定ALL患者化疗后灰质体积改变的一致模式。材料和方法：在PubMed、Web of Knowledge、Embase、谷歌Scholar和CNKI上进行了系统检索，以比较截至2024年4月1日化疗后ALL患者与健康对照（hc）的VBM研究。提取显著聚类坐标进行综合分析。结果：我们纳入了7项研究，涉及143名化疗后ALL患者和140名hcc患者。所有接受化疗的患者均表现为左侧尾状核、左侧钙状裂/周围皮层、左侧中央前回和右侧丘脑前投影的灰质体积减少。Jackknife敏感性分析验证了这些发现的稳健性。结论：这项荟萃分析揭示了ALL患者化疗后灰质体积的一致改变，强调有必要探索其潜在机制和对认知和神经健康的长期影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Medical Research 医学-医学：研究与实验

CiteScore

3.20

自引率

0.00%

发文量

247

审稿时长

>12 weeks

期刊介绍： European Journal of Medical Research publishes translational and clinical research of international interest across all medical disciplines, enabling clinicians and other researchers to learn about developments and innovations within these disciplines and across the boundaries between disciplines. The journal publishes high quality research and reviews and aims to ensure that the results of all well-conducted research are published, regardless of their outcome.