Global trends and prospects of ocular biomarkers in Alzheimer's disease: a bibliometric analysis.

IF 4.1 2区医学 Q2 GERIATRICS & GERONTOLOGY

Frontiers in Aging Neuroscience Pub Date : 2025-03-19 eCollection Date: 2025-01-01 DOI:10.3389/fnagi.2025.1528527

Yufei Shen, Xiaoling Zhang, Congying Xu, Zhuoying Zhu

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引用次数: 0

Abstract

Background: Alzheimer's disease (AD) diagnosis necessitates the development of novel biomarkers that ensure high diagnostic accuracy and cost-effectiveness in blood tests. Recent studies have identified a significant association between ocular symptoms and the pathological processes of AD, suggesting the potential for effective ocular biomarkers. This bibliometric analysis aims to explore recent advancements and research trends in ocular biomarkers for the early diagnosis of AD.

Methods: Articles related to AD and ocular biomarkers were retrieved from the Web of Science Core Collection (WoSCC) database. These articles were analyzed using bibliometric tools such as VOSviewer, R-bibliometrix, and CiteSpace.

Results: A total of 623 papers were included in the analysis, revealing a steady increase in publications since 2012. The United States produced the most publications, followed by China and Italy. Notably, authors affiliated with Complutense University of Madrid in Spain and Sapienza University of Rome in Italy made significant contributions, demonstrating robust internal collaborations. The Journal of Alzheimer's Disease published the most articles pertaining to ocular science and neuroscience. Keyword analysis indicates evolving trends in ocular markers for AD from 2005 to 2024, transitioning from diagnostic techniques (e.g., "spectroscopy," "cerebrospinal fluid") to pathological mechanisms (e.g., "oxidative stress") and advanced imaging technologies (e.g., "optical coherence tomography angiography").

Conclusion: The bibliometric analysis highlights key research hotspots related to ocular markers for AD, documenting the shift from basic diagnostic techniques to advanced imaging methods and the discovery of novel biomarkers. Future research may investigate the potential of Optical Coherence Tomography Angiography, tear component analysis, eye movement assessments, and artificial intelligence to enhance early detection of AD.

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来源期刊

Frontiers in Aging Neuroscience GERIATRICS & GERONTOLOGY-NEUROSCIENCES

CiteScore

6.30

自引率

8.30%

发文量

1426

期刊介绍： Frontiers in Aging Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the mechanisms of Central Nervous System aging and age-related neural diseases. Specialty Chief Editor Thomas Wisniewski at the New York University School of Medicine is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.