Abnormal cerebellar activity and connectivity alterations of the cerebellar-limbic system in post-stroke cognitive impairment: a study based on resting state functional magnetic resonance imaging.

IF 3.2 3区医学 Q2 NEUROSCIENCES

Frontiers in Neuroscience Pub Date : 2025-03-19 eCollection Date: 2025-01-01 DOI:10.3389/fnins.2025.1543760

Haiyi Zhang, Juan Lu, Lu Zhang, Jidan Hu, Jiajun Yue, Yunhan Ma, Qi Yao, Pingping Jie, Min Fan, Jiliang Fang, Jie Zhao

{"title":"Abnormal cerebellar activity and connectivity alterations of the cerebellar-limbic system in post-stroke cognitive impairment: a study based on resting state functional magnetic resonance imaging.","authors":"Haiyi Zhang, Juan Lu, Lu Zhang, Jidan Hu, Jiajun Yue, Yunhan Ma, Qi Yao, Pingping Jie, Min Fan, Jiliang Fang, Jie Zhao","doi":"10.3389/fnins.2025.1543760","DOIUrl":null,"url":null,"abstract":"Background: Stroke is an important cause of cognitive impairment. Post-stroke cognitive impairment (PSCI) is a prevalent psychiatric disorder following stroke. However, the effects of PSCI on the cerebellum remain mostly unknown.Methods: A total of 31 PSCI patients and 31 patients without cognitive impairment after stroke were included in this study. The Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) were administered to all participants. Analyses of ALFF, fALFF, and ReHo were employed to investigate alterations in brain neuronal activity, while limbic connectivity analysis was utilized to reflect changes within the abnormal connections within brain regions.Results: We found that ALFF values were increased in Cerebelum_7b_R, Cerebelum_Crus1_L. fALFF values were increased in Vermis_3. The ReHo values were increased in Cerebelum_8_R, Cerebelum_Crus2_R, Cerebelum_Crus1_L. The functional connection between Frontal_Mid_Orb_L and Cerebelum_Crus2_R brain regions was decreased. The functional connection between Hippocampus_L and Cerebelum_Crus2_R brain regions was decreased. The functional connection between Vermis_3 and Frontal_Med_Orb_L brain regions was decreased.Conclusion: The severity of cognitive impairment may influence the extent of functional connectivity disruption between the cerebellum and the limbic system. Furthermore, atypical alterations in neuronal activity within cerebellar regions are associated with cognitive decline.","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1543760"},"PeriodicalIF":3.2000,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11962788/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fnins.2025.1543760","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Stroke is an important cause of cognitive impairment. Post-stroke cognitive impairment (PSCI) is a prevalent psychiatric disorder following stroke. However, the effects of PSCI on the cerebellum remain mostly unknown.

Methods: A total of 31 PSCI patients and 31 patients without cognitive impairment after stroke were included in this study. The Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) were administered to all participants. Analyses of ALFF, fALFF, and ReHo were employed to investigate alterations in brain neuronal activity, while limbic connectivity analysis was utilized to reflect changes within the abnormal connections within brain regions.

Results: We found that ALFF values were increased in Cerebelum_7b_R, Cerebelum_Crus1_L. fALFF values were increased in Vermis_3. The ReHo values were increased in Cerebelum_8_R, Cerebelum_Crus2_R, Cerebelum_Crus1_L. The functional connection between Frontal_Mid_Orb_L and Cerebelum_Crus2_R brain regions was decreased. The functional connection between Hippocampus_L and Cerebelum_Crus2_R brain regions was decreased. The functional connection between Vermis_3 and Frontal_Med_Orb_L brain regions was decreased.

Conclusion: The severity of cognitive impairment may influence the extent of functional connectivity disruption between the cerebellum and the limbic system. Furthermore, atypical alterations in neuronal activity within cerebellar regions are associated with cognitive decline.

查看原文本刊更多论文

脑卒中后认知障碍患者小脑-边缘系统异常活动和连通性改变：基于静息状态功能磁共振成像的研究

背景：脑卒中是认知功能障碍的重要原因。脑卒中后认知障碍（PSCI）是脑卒中后常见的精神障碍。然而，PSCI对小脑的影响仍然是未知的。方法：选取31例PSCI患者和31例脑卒中后无认知功能障碍患者作为研究对象。对所有参与者进行简易精神状态检查（MMSE）和蒙特利尔认知评估（MoCA）。通过分析ALFF、fALFF和ReHo来研究大脑神经元活动的变化，而通过边缘连通性分析来反映大脑区域内异常连接的变化。结果：我们发现小脑区7b_r、小脑区crus1_l的ALFF值升高。Vermis_3增加了fALFF值。Cerebelum_8_R、Cerebelum_Crus2_R、Cerebelum_Crus1_L的ReHo值升高。Frontal_Mid_Orb_L和Cerebelum_Crus2_R脑区之间的功能连接减少。海马l和小脑cr2_r区域之间的功能连接减弱。Vermis_3与Frontal_Med_Orb_L脑区的功能连接减弱。结论：认知障碍的严重程度可能影响小脑与边缘系统功能连接中断的程度。此外，小脑区域内神经元活动的非典型改变与认知能力下降有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Frontiers in Neuroscience NEUROSCIENCES-

CiteScore

6.20

自引率

4.70%

发文量

2070

审稿时长

14 weeks

期刊介绍： Neural Technology is devoted to the convergence between neurobiology and quantum-, nano- and micro-sciences. In our vision, this interdisciplinary approach should go beyond the technological development of sophisticated methods and should contribute in generating a genuine change in our discipline.