To investigate the effect of neck-shaft angle in surgical hip dislocation combined with femoral neck rotational osteotomy in the treatment of osteonecrosis of the femoral head and to combine with finite element analysis.

IF 4.3 3区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Frontiers in Bioengineering and Biotechnology Pub Date : 2025-03-19 eCollection Date: 2025-01-01 DOI:10.3389/fbioe.2025.1495292

Sun Jiahao, Ma Bowen, Zhang Chiyu, Xia Tianwei, Shen Jirong, Zhang Chao

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引用次数: 0

Abstract

Background: The Neck-shaft Angle (NSA) is a reliable predictor of the outcome of internal fixation for femoral neck fractures. Surgical Hip Dislocation Combined with Femoral Neck Rotational Osteotomy (SHD-FNRO) is an effective surgical method for treating femoral head necrosis. However, the potential role of NSA in predicting the outcomes of hip preservation after SHD-FNRO has not been explored.

Objective: This study aims to investigate the value of NSA in predicting the outcomes of hip preservation after SHD-FNRO by comparing the results among different patients with osteonecrosis of the femoral head (ONFH) who were treated with SHD-FNRO.

Methods: We retrospectively analyzed clinical data from 33 patients (33 hips) who underwent SHD-FNRO at our hospital between January 2017 and December 2021. Based on the outcome of hip preservation, patients were divided into two groups: group A (successful hip preservation) and group B (failed hip preservation). Statistical analysis was performed to evaluate any differences between these groups. Additionally, three-dimensional models with varying NSA values were created to analyze changes in maximum displacement and stress on the osteotomy surface.

Results: During a mean follow-up period of approximately 40 months, successful hip preservation was achieved in 26 patients while 7 patients experienced failure. There was a statistically significant difference in NSA between these two groups (P < 0.05). Biomechanical analysis demonstrated a close relationship between NSA and postoperative biomechanical changes.

Conclusion: The size of NSA is closely associated with the success rate of hip preservation when treating osteonecrosis of the femoral head using SHD-FNRO. Therefore, careful attention should be given to selecting an appropriate osteotomy surface that can adjust NSA size effectively, thus achieving better outcomes for hip preservation.

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来源期刊

Frontiers in Bioengineering and Biotechnology Chemical Engineering-Bioengineering

CiteScore

8.30

自引率

5.30%

发文量

2270

审稿时长

12 weeks

期刊介绍： The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs. In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.