Exploring the Impact of Guselkumab and Risankizumab on Psoriasis in HIV-Positive Patients: Insights From Four Italian Centers.

IF 2.2 4区医学 Q2 DERMATOLOGY

Australasian Journal of Dermatology Pub Date : 2025-04-03 DOI:10.1111/ajd.14467

V Maione, S Rovaris, C Romanó, S Bighetti, M Arisi, C G Carrera, F Bellinato, P Gisondi, Z Fratton, E Errichetti, L Bettolini

引用次数: 0

Abstract

HIV-positive patients with psoriasis often face delays in accessing biologic therapies due to their exclusion from clinical trials and concerns about the impact of immunomodulatory drugs on viral replication. Anti-IL-23 therapies, such as risankizumab and guselkumab, have shown great promise thanks to their strong efficacy and favourable safety profiles. A case series from four Italian centres reported sustained effectiveness of these drugs, with no observed effects on viral replication or immune parameters in HIV-positive patients. Although the number of cases is limited, these therapies appear to be a compelling option for patients with extensive or treatment-resistant psoriasis.

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探索Guselkumab和Risankizumab对hiv阳性患者银屑病的影响：来自四个意大利中心的见解。

由于hiv阳性的牛皮癣患者被排除在临床试验之外，并且担心免疫调节药物对病毒复制的影响，他们经常面临获得生物治疗的延迟。抗il -23疗法，如risankizumab和guselkumab，由于其强大的疗效和良好的安全性，已经显示出巨大的希望。来自意大利四个中心的病例系列报告了这些药物的持续有效性，未观察到对艾滋病毒阳性患者的病毒复制或免疫参数的影响。尽管病例数量有限，但这些疗法似乎是广泛或治疗抵抗性牛皮癣患者的一个令人信服的选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Australasian Journal of Dermatology 医学-皮肤病学

CiteScore

3.20

自引率

5.00%

发文量

186

审稿时长

6-12 weeks

期刊介绍： Australasian Journal of Dermatology is the official journal of the Australasian College of Dermatologists and the New Zealand Dermatological Society, publishing peer-reviewed, original research articles, reviews and case reports dealing with all aspects of clinical practice and research in dermatology. Clinical presentations, medical and physical therapies and investigations, including dermatopathology and mycology, are covered. Short articles may be published under the headings ‘Signs, Syndromes and Diagnoses’, ‘Dermatopathology Presentation’, ‘Vignettes in Contact Dermatology’, ‘Surgery Corner’ or ‘Letters to the Editor’.