Prognostic role of IL-34 in sepsis and sepsis-induced acute lung injury: preliminary results and future directions.

IF 1.4 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Acta biochimica Polonica Pub Date : 2025-03-19 eCollection Date: 2025-01-01 DOI:10.3389/abp.2025.13958
Run Cai, Jianke Ren, Chenwei Zhou, Yuxin Liu, Jianlei Tang, Weiyan Cui, Yongmin Yan, Sheliang Xue, Yanjuan Zhou
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引用次数: 0

Abstract

Objective: This study aimed to evaluate the potential of interleukin-34 (IL-34) as a novel biomarker for predicting mortality in sepsis patients, with a specific focus on those with sepsis-induced acute lung injury (ALI).

Methods: This prospective cohort study enrolled 115 sepsis patients admitted to the intensive care unit (ICU). The patients were divided into survival and non-survival groups, as well as ALI and non-ALI subgroups. Serum levels of IL-34, in conjunction with other established biomarkers such as interleukin-6 (IL-6), C-reactive protein (CRP), and lactate, were measured and analyzed. Statistical analyses, including receiver operating characteristic (ROC) curves, Kaplan-Meier survival curves and Cox regression models, were used to determine the prognostic significance of IL-34.

Results: Serum IL-34 levels were significantly elevated in sepsis patients compared to healthy controls, and they were also higher in non-survival group compared to survival group (p < 0.05). Additionally, IL-34 levels exhibited a positive correlation with sepsis severity, as indicated by APACHE II and SOFA scores. Kaplan-Meier survival curves and multivariate COX regression analysis revealed that IL-34 is an independent risk factor for death within 28 days of sepsis. The serum IL-34 level in the ALI group was significantly higher than that in the non-ALI group, particularly in severe cases (p < 0.05). However, the prognostic value of IL-34 in sepsis-induced ALI requires further investigation.

Conclusion: IL-34 shows promise as an independent prognostic factor in sepsis patients and may enhance risk stratification, especially in those with sepsis-induced ALI.

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来源期刊
Acta biochimica Polonica
Acta biochimica Polonica 生物-生化与分子生物学
CiteScore
2.40
自引率
0.00%
发文量
99
审稿时长
4-8 weeks
期刊介绍: Acta Biochimica Polonica is a journal covering enzymology and metabolism, membranes and bioenergetics, gene structure and expression, protein, nucleic acid and carbohydrate structure and metabolism.
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