{"title":"Prognostic role of IL-34 in sepsis and sepsis-induced acute lung injury: preliminary results and future directions.","authors":"Run Cai, Jianke Ren, Chenwei Zhou, Yuxin Liu, Jianlei Tang, Weiyan Cui, Yongmin Yan, Sheliang Xue, Yanjuan Zhou","doi":"10.3389/abp.2025.13958","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the potential of interleukin-34 (IL-34) as a novel biomarker for predicting mortality in sepsis patients, with a specific focus on those with sepsis-induced acute lung injury (ALI).</p><p><strong>Methods: </strong>This prospective cohort study enrolled 115 sepsis patients admitted to the intensive care unit (ICU). The patients were divided into survival and non-survival groups, as well as ALI and non-ALI subgroups. Serum levels of IL-34, in conjunction with other established biomarkers such as interleukin-6 (IL-6), C-reactive protein (CRP), and lactate, were measured and analyzed. Statistical analyses, including receiver operating characteristic (ROC) curves, Kaplan-Meier survival curves and Cox regression models, were used to determine the prognostic significance of IL-34.</p><p><strong>Results: </strong>Serum IL-34 levels were significantly elevated in sepsis patients compared to healthy controls, and they were also higher in non-survival group compared to survival group (<i>p</i> < 0.05). Additionally, IL-34 levels exhibited a positive correlation with sepsis severity, as indicated by APACHE II and SOFA scores. Kaplan-Meier survival curves and multivariate COX regression analysis revealed that IL-34 is an independent risk factor for death within 28 days of sepsis. The serum IL-34 level in the ALI group was significantly higher than that in the non-ALI group, particularly in severe cases (<i>p</i> < 0.05). However, the prognostic value of IL-34 in sepsis-induced ALI requires further investigation.</p><p><strong>Conclusion: </strong>IL-34 shows promise as an independent prognostic factor in sepsis patients and may enhance risk stratification, especially in those with sepsis-induced ALI.</p>","PeriodicalId":6984,"journal":{"name":"Acta biochimica Polonica","volume":"72 ","pages":"13958"},"PeriodicalIF":1.4000,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963693/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta biochimica Polonica","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.3389/abp.2025.13958","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: This study aimed to evaluate the potential of interleukin-34 (IL-34) as a novel biomarker for predicting mortality in sepsis patients, with a specific focus on those with sepsis-induced acute lung injury (ALI).
Methods: This prospective cohort study enrolled 115 sepsis patients admitted to the intensive care unit (ICU). The patients were divided into survival and non-survival groups, as well as ALI and non-ALI subgroups. Serum levels of IL-34, in conjunction with other established biomarkers such as interleukin-6 (IL-6), C-reactive protein (CRP), and lactate, were measured and analyzed. Statistical analyses, including receiver operating characteristic (ROC) curves, Kaplan-Meier survival curves and Cox regression models, were used to determine the prognostic significance of IL-34.
Results: Serum IL-34 levels were significantly elevated in sepsis patients compared to healthy controls, and they were also higher in non-survival group compared to survival group (p < 0.05). Additionally, IL-34 levels exhibited a positive correlation with sepsis severity, as indicated by APACHE II and SOFA scores. Kaplan-Meier survival curves and multivariate COX regression analysis revealed that IL-34 is an independent risk factor for death within 28 days of sepsis. The serum IL-34 level in the ALI group was significantly higher than that in the non-ALI group, particularly in severe cases (p < 0.05). However, the prognostic value of IL-34 in sepsis-induced ALI requires further investigation.
Conclusion: IL-34 shows promise as an independent prognostic factor in sepsis patients and may enhance risk stratification, especially in those with sepsis-induced ALI.
期刊介绍:
Acta Biochimica Polonica is a journal covering enzymology and metabolism, membranes and bioenergetics, gene structure and expression, protein, nucleic acid and carbohydrate structure and metabolism.