Mihee Oh, Sunha Lee, Eunhye Kim, Yewon Jang, Baek-Soo Han
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引用次数: 0
Abstract
Parkinson's disease (PD) is the second most common neurodegenerative disorder, characterized by the degeneration of dopaminergic neurons, striatal dopamine deficiency, and the accumulation of intracellular α-synuclein aggregates. In this study, we employed induced pluripotent stem cell (iPSC) technology to generate dopaminergic neurons from somatic cells of both PD patients and healthy controls. Our results demonstrate that patient-derived neurons exhibit elevated expression of vascular cell adhesion molecule 1 (VCAM1), which correlates with altered synaptic plasticity, mitochondrial dysfunction, and impaired Rac1 and FAK2 signaling. These findings suggest that VCAM1 plays a pivotal role in PD pathogenesis and may serve as a potential therapeutic target.
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The BMB Reports (BMB Rep, established in 1968) is published at the end of every month by Korean Society for Biochemistry and Molecular Biology. Copyright is reserved by the Society. The journal publishes short articles and mini reviews. We expect that the BMB Reports will deliver the new scientific findings and knowledge to our readers in fast and timely manner.
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