"SERBP1 (Hero45) is a Novel Link with Ischemic Heart Disease Risk: Associations with Coronary Arteries Occlusion, Blood Coagulation and Lipid Profile".

IF 1.8 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Biochemistry and Biophysics Pub Date : 2025-04-03 DOI:10.1007/s12013-025-01736-z

Vladislav Shilenok, Ksenia Kobzeva, Olga Bushueva

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引用次数: 0

Abstract

Ischemic heart disease (IHD), stemming from coronary atherosclerosis, involves pathological processes in which chaperone proteins play an essential role. SERBP1 (Hero45), an RNA-binding protein, has recently been ascribed to the newly discovered class of Hero proteins with chaperone-like activity, making it particularly relevant in atherosclerosis-related diseases. In this study, 2164 subjects (836 IHD patients and 1328 controls) were genotyped for five common single nucleotide polymorphisms (SNPs) of SERBP1 using probe-based PCR. Here, we report that SNPs of SERBP1 are associated with reduced risk of left coronary artery atherosclerosis: rs4655707 (effect allele [EA] T, OR = 0.63, 95% CI 0.43-0.93, p = 0.02), (EA C, OR = 0.63, 95% CI 0.42-0.95, p = 0.02), rs12561767 (EA G, OR = 0.65, 95% CI 0.45-0.96, p = 0.03), rs6702742 (EA A, OR = 0.63, 95% CI 0.43-0.94, p = 0.02). Additionally, SERBP1 loci are linked to lower coronary artery stenosis (rs1058074), improved blood lipid profiles (rs1058074), and favorable blood coagulation parameters (rs4655707, rs6702742, rs1058074, rs12561767). Together, our study is the first to provide evidence that SERBP1 is involved in lipid metabolism and coagulation regulation, modulating IHD risk.

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SERBP1 （Hero45）是缺血性心脏病风险的新联系：与冠状动脉闭塞、血液凝固和血脂相关。

缺血性心脏病（IHD）起源于冠状动脉粥样硬化，涉及伴侣蛋白在其中起重要作用的病理过程。SERBP1 （Hero45）是一种rna结合蛋白，最近被归因于新发现的一类具有伴侣样活性的Hero蛋白，使其与动脉粥样硬化相关疾病特别相关。在这项研究中，2164名受试者（836名IHD患者和1328名对照）使用探针PCR对SERBP1的5个常见单核苷酸多态性（snp）进行了基因分型。在这里，我们报道SERBP1的snp与左冠状动脉粥样硬化风险降低相关：rs4655707（效应等位基因[EA] T， OR = 0.63, 95% CI 0.43-0.93, p = 0.02），（EA C, OR = 0.63, 95% CI 0.42-0.95, p = 0.02）， rs12561767 (EA G, OR = 0.65, 95% CI 0.45-0.96, p = 0.03), rs6702742 （EA A, OR = 0.63, 95% CI 0.43-0.94, p = 0.02）。此外，SERBP1位点与较低的冠状动脉狭窄（rs1058074）、改善的血脂（rs1058074）和有利的凝血参数（rs4655707、rs6702742、rs1058074、rs12561767）有关。总之，我们的研究首次提供了SERBP1参与脂质代谢和凝血调节，调节IHD风险的证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Biochemistry and Biophysics 生物-生化与分子生物学

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

7.5 months

期刊介绍： Cell Biochemistry and Biophysics (CBB) aims to publish papers on the nature of the biochemical and biophysical mechanisms underlying the structure, control and function of cellular systems The reports should be within the framework of modern biochemistry and chemistry, biophysics and cell physiology, physics and engineering, molecular and structural biology. The relationship between molecular structure and function under investigation is emphasized. Examples of subject areas that CBB publishes are: · biochemical and biophysical aspects of cell structure and function; · interactions of cells and their molecular/macromolecular constituents; · innovative developments in genetic and biomolecular engineering; · computer-based analysis of tissues, cells, cell networks, organelles, and molecular/macromolecular assemblies; · photometric, spectroscopic, microscopic, mechanical, and electrical methodologies/techniques in analytical cytology, cytometry and innovative instrument design For articles that focus on computational aspects, authors should be clear about which docking and molecular dynamics algorithms or software packages are being used as well as details on the system parameterization, simulations conditions etc. In addition, docking calculations (virtual screening, QSAR, etc.) should be validated either by experimental studies or one or more reliable theoretical cross-validation methods.