Leveraging dielectrophoresis in inertial flow for versatile manipulation of micro and nanoparticles.

IF 6.1 2区 工程技术 Q1 BIOCHEMICAL RESEARCH METHODS
Lab on a Chip Pub Date : 2025-04-03 DOI:10.1039/d4lc01037j
Haotian Cha, Lingxi Ouyang, Xiangxun Chen, Yuao Wu, Xiaoyue Kang, Hongjie An, Weihua Li, Nam-Trung Nguyen, Jun Zhang
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引用次数: 0

Abstract

The manipulation of micro and nanoparticles has extensive applications in biomedical research, clinical diagnostics, environmental monitoring, drug discovery, and the mining industry. Dielectrophoresis (DEP) utilises nonuniform electric fields to manipulate particles, offering a label-free, high-precision, and non-invasive method for both natural and synthetic particles. DEP manipulation has been well studied in the Stokes flow region with ultra-low Reynolds numbers (Re ≪ 1), where viscous effects dominate. However, its application in the inertial flow regime remains largely unexplored. This study aims to bridge the gap by coupling DEP and inertial flow for the manipulation of particles across micro and nano scales. First, we theoretically analysed the physical coupling of DEP and inertial lift forces along the vertical direction in microchannels, utilising symmetrical interdigitated electrode (IDE) arrays patterned on the top and bottom channel surfaces. We then experimentally investigated how the vertical coupling of DEP and inertial lift forces affects particle lateral focusing properties. The effects of DEP along the vertical direction were leveraged and amplified by the inertial effects along the lateral direction. Finally, we applied DEP in the inertial flow regime for size-based and dielectric property-based separation of particles and cells, as well as nanoparticle focusing and filtration. We believe that leveraging DEP in inertial flow will advance the field by providing a versatile and powerful method for the manipulation of micro and nanoparticles.

利用惯性流介质电泳对微粒子和纳米粒子进行多功能操作。
微粒子和纳米粒子的操作在生物医学研究、临床诊断、环境监测、药物发现和采矿业中有着广泛的应用。Dielectrophoresis (DEP)利用非均匀电场来操纵粒子,为天然和合成粒子提供了一种无标签、高精度和非侵入性的方法。在具有超低雷诺数(Re≪1)的Stokes流区,对DEP操纵进行了很好的研究,该区域的粘性效应占主导地位。然而,它在惯性流动中的应用在很大程度上仍未被探索。本研究旨在通过耦合DEP和惯性流来跨越微纳米尺度操纵粒子来弥补这一差距。首先,我们从理论上分析了DEP和惯性升力沿垂直方向在微通道中的物理耦合,利用对称的交叉电极(IDE)阵列图案在顶部和底部的通道表面。然后,我们实验研究了DEP和惯性升力的垂直耦合如何影响粒子的横向聚焦特性。沿垂直方向的DEP效应被沿横向的惯性效应所撬动和放大。最后,我们将DEP应用于基于尺寸和介电性质的颗粒和细胞分离,以及纳米颗粒聚焦和过滤的惯性流动模式。我们相信,利用惯性流中的DEP将为微粒子和纳米粒子的操纵提供一种多功能和强大的方法,从而推动该领域的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Lab on a Chip
Lab on a Chip 工程技术-化学综合
CiteScore
11.10
自引率
8.20%
发文量
434
审稿时长
2.6 months
期刊介绍: Lab on a Chip is the premiere journal that publishes cutting-edge research in the field of miniaturization. By their very nature, microfluidic/nanofluidic/miniaturized systems are at the intersection of disciplines, spanning fundamental research to high-end application, which is reflected by the broad readership of the journal. Lab on a Chip publishes two types of papers on original research: full-length research papers and communications. Papers should demonstrate innovations, which can come from technical advancements or applications addressing pressing needs in globally important areas. The journal also publishes Comments, Reviews, and Perspectives.
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